Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person The exact role of SHC1 in FGFR signaling remains unclear. ...
| Class:Id | Summation:532260 |
|---|
| _displayName | The exact role of SHC1 in FGFR signaling remains unclear. ... |
|---|
| _timestamp | 2011-05-31 14:44:40 |
|---|
| created | [InstanceEdit:532261] Jupe, S, 2010-02-26 |
|---|
| literatureReference | [LiteratureReference:532255] Fibroblast growth factor receptors have different signaling and mitogenic potentials
[LiteratureReference:532244] Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells
[LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.
[LiteratureReference:191036] Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells
[LiteratureReference:532248] Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2) |
|---|
| modified | [InstanceEdit:1268196] Rothfels, K, 2011-05-09
[InstanceEdit:1315554] Rothfels, K, 2011-05-31 |
|---|
| text | The exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction with the receptor has not been demonstrated. Co-precipitation of p46 and p52 with the FGFR2 IIIc receptor has been reported, but this interaction is thought to be indirect, possibly mediated by SRC. Consistent with this, co-precipitation of SHC1 and FGFR1 IIIc is seen in mammalian cells expressing v-SRC. The p66 isoform of SHC1 has also been co-precipitated with FGFR3, but this occurs independently of receptor stimulation, and the p66 isoform not been shown to undergo FGF-dependent phosphorylation. SHC1 has been shown to associate with GRB2 and SOS1 in response to FGF stimulation, suggesting that the recruitment of SHC1 may contribute to activation of the MAPK cascade downstream of FGFR. |
|---|
| (summation) | [Pathway:5654688] SHC-mediated cascade:FGFR1 [Homo sapiens]
[Pathway:5654699] SHC-mediated cascade:FGFR2 [Homo sapiens]
[Pathway:5654704] SHC-mediated cascade:FGFR3 [Homo sapiens]
[Pathway:5654719] SHC-mediated cascade:FGFR4 [Homo sapiens] |
|---|
|
[Change default viewing format]
|
No pathways have been reviewed or authored by The exact role of SHC1 in FGFR signaling remains unclear. ... (532260)
