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Details on Person UniProt:P30825 SLC7A1
| Class:Id | ReferenceGeneProduct:53062 |
|---|---|
| _chainChangeLog | chain:1-629 added on Fri February 6 2015 |
| _displayName | UniProt:P30825 SLC7A1 |
| _timestamp | 2024-11-03 20:13:54 |
| chain | chain:1-629 |
| checksum | 717734D4793647C5 |
| comment | FUNCTION High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.CATALYTIC ACTIVITY L-arginine(in) = L-arginine(out)CATALYTIC ACTIVITY L-lysine(in) = L-lysine(out)CATALYTIC ACTIVITY L-ornithine(in) = L-ornithine(out)CATALYTIC ACTIVITY L-homoarginine(in) = L-homoarginine(out)BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 5.5-8.5.SUBUNIT Interacts with TM4SF5; the interaction is negatively regulated by arginine (PubMed:30956113). Forms tissue-specific complexes with ASL, ASS1 and nitric oxide synthase NOS1 or NOS3; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity).INTERACTION Ubiquitous.SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. |
| description | recommendedName: High affinity cationic amino acid transporter 1 shortName evidence="8"CAT-1 shortName: CAT1 alternativeName: Ecotropic retroviral leukemia receptor homolog alternativeName: Ecotropic retrovirus receptor homolog alternativeName: fullName evidence="11"Solute carrier family 7 member 1 alternativeName: System Y+ basic amino acid transporter |
| geneName | SLC7A1 ATRC1 ERR REC1L |
| identifier | P30825 |
| isSequenceChanged | FALSE |
| keyword | Amino-acid transport Cell membrane Direct protein sequencing Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SLC7A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999995] ENSEMBL:ENSG00000139514 SLC7A1 [Homo sapiens] |
| secondaryIdentifier | CTR1_HUMAN Q5JR50 |
| sequenceLength | 629 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:375771] SLC7A1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P30825 SLC7A1 (53062)
