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Details on Person UniProt:O60716 CTNND1
| Class:Id | ReferenceGeneProduct:52998 |
|---|---|
| _chainChangeLog | chain:1-968 added on Fri February 6 2015 |
| _displayName | UniProt:O60716 CTNND1 |
| _timestamp | 2025-02-21 18:55:32 |
| chain | chain:1-968 |
| checksum | D5C37489A891F292 |
| comment | FUNCTION Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476).SUBUNIT Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin/CDH1, alpha-catenin/CTNNA1, beta-catenin/CTNNB1, and gamma-catenin/JUP (PubMed:15240885, PubMed:20371349). Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (PubMed:28051089). Binds to the C-terminal fragment of PSEN1 and mutually competes for CDH1. Interacts with ZBTB33 (PubMed:10207085). Interacts with GLIS2 (PubMed:17344476). Interacts with FER (PubMed:7623846). Interacts with NANOS1 (via N-terminal region) (PubMed:17047063). Interacts (via N-terminus) with GNA12; the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885). Interacts with GNA13 (PubMed:15240885). Interacts with CCDC85B (PubMed:25009281). Interacts with PLPP3; negatively regulates the PLPP3-mediated stabilization of CTNNB1 (PubMed:20123964). Interacts with DSG3; the interaction facilitates DSG3 localization and retention at cell-cell junctions (PubMed:18343367). Interacts with CTNND1/p120-catenin; the interaction controls CADH5 endocytosis (By similarity).INTERACTION Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity).SUBCELLULAR LOCATION Isoforms result of a combination of four transcription start sites and three alternatively spliced exons(A, B and C).TISSUE SPECIFICITY Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.INDUCTION Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.DOMAIN A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.DOMAIN ARM repeats 1 to 5 mediate interaction with cadherins.PTM Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the beta-catenin family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Catenin delta-1 alternativeName: Cadherin-associated Src substrate shortName: CAS alternativeName: p120 catenin shortName: p120(ctn) alternativeName: p120(cas) |
| geneName | CTNND1 KIAA0384 |
| identifier | O60716 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative initiation Alternative splicing Cell adhesion Cell junction Cell membrane Coiled coil Cytoplasm Disease variant Ectodermal dysplasia Isopeptide bond Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CTNND1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988902] ENSEMBL:ENSG00000198561 CTNND1 [Homo sapiens] |
| secondaryIdentifier | CTND1_HUMAN A8K939 O15088 O60713 O60714 O60715 O60935 Q6DHZ7 Q6RBX8 Q9UP71 Q9UP72 Q9UP73 |
| sequenceLength | 968 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:146036] UniProt:O60716-2 CTNND1 [Homo sapiens] [ReferenceIsoform:146037] UniProt:O60716-3 CTNND1 [Homo sapiens] [ReferenceIsoform:146038] UniProt:O60716-4 CTNND1 [Homo sapiens] [ReferenceIsoform:146039] UniProt:O60716-5 CTNND1 [Homo sapiens] [ReferenceIsoform:146040] UniProt:O60716-6 CTNND1 [Homo sapiens] [ReferenceIsoform:146041] UniProt:O60716-7 CTNND1 [Homo sapiens] [ReferenceIsoform:146042] UniProt:O60716-8 CTNND1 [Homo sapiens] [ReferenceIsoform:146043] UniProt:O60716-9 CTNND1 [Homo sapiens] [ReferenceIsoform:146044] UniProt:O60716-10 CTNND1 [Homo sapiens] [ReferenceIsoform:146045] UniProt:O60716-11 CTNND1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:418996] CTNND1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9934835] p-Y-CTNND1 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9934828] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:O60716 CTNND1 (52998)
