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Details on Person UniProt:Q9NUV7 SPTLC3
| Class:Id | ReferenceGeneProduct:52918 |
|---|---|
| _chainChangeLog | chain:1-552 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NUV7 SPTLC3 |
| _timestamp | 2025-02-21 18:52:05 |
| chain | chain:1-552 |
| checksum | EED341220DCA683A |
| comment | FUNCTION Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851, PubMed:19648650). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851, PubMed:19648650).CATALYTIC ACTIVITY L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoACATALYTIC ACTIVITY dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoACATALYTIC ACTIVITY tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoACATALYTIC ACTIVITY octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoACOFACTOR SPT complex catalytic activity is negatively regulated by ORMDL proteins, including ORMDL3, in the presence of ceramides (By similarity). This mechanism allows to maintain ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (Probable).BIOPHYSICOCHEMICAL PROPERTIES Lipid metabolism; sphingolipid metabolism.SUBUNIT Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity (PubMed:19416851). SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides (By similarity).INTERACTION Expressed in most tissues, except peripheral blood cells and bone marrow, with highest levels in heart, kidney, liver, uterus and skin.SIMILARITY Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| description | recommendedName: fullName evidence="12"Serine palmitoyltransferase 3 ecNumber evidence="7 8"2.3.1.50 alternativeName: Long chain base biosynthesis protein 2b shortName evidence="11"LCB2b alternativeName: Long chain base biosynthesis protein 3 shortName: LCB 3 alternativeName: Serine-palmitoyl-CoA transferase 3 shortName: SPT 3 |
| geneName | SPTLC3 C20orf38 SPTLC2L |
| identifier | Q9NUV7 |
| isSequenceChanged | FALSE |
| keyword | Acyltransferase Alternative splicing Endoplasmic reticulum Lipid metabolism Membrane Proteomics identification Pyridoxal phosphate Reference proteome Sphingolipid metabolism Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SPTLC3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993331] ENSEMBL:ENSG00000172296 SPTLC3 [Homo sapiens] |
| secondaryIdentifier | SPTC3_HUMAN A2A2I4 B9EK64 Q05DQ8 Q5T1U4 Q9H1L1 Q9H1Z0 |
| sequenceLength | 552 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:249307] UniProt:Q9NUV7-2 SPTLC3 [Homo sapiens] [ReferenceIsoform:414807] UniProt:Q9NUV7-1 SPTLC3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:428162] PXLP-K371-SPTLC3 [endoplasmic reticulum membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:554222] N6-pyridoxal phosphate-L-lysine at 371 |
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No pathways have been reviewed or authored by UniProt:Q9NUV7 SPTLC3 (52918)
