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Details on Person UniProt:O43513 MED7

Class:IdReferenceGeneProduct:52872
_chainChangeLogchain:1-233 added on Fri February 6 2015
_displayNameUniProt:O43513 MED7
_timestamp2024-11-03 20:15:17
chainchain:1-233
checksum9D95A2A8360B9C62
commentFUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.INTERACTION Constitutively sumoylated.SIMILARITY Belongs to the Mediator complex subunit 7 family.
created[InstanceEdit:212387] Caudy, M, 2008-02-08 22:45:45
descriptionrecommendedName: Mediator of RNA polymerase II transcription subunit 7 shortName: hMED7 alternativeName: Activator-recruited cofactor 34 kDa component shortName: ARC34 alternativeName: Cofactor required for Sp1 transcriptional activation subunit 9 shortName: CRSP complex subunit 9 alternativeName: Mediator complex subunit 7 alternativeName: RNA polymerase transcriptional regulation mediator subunit 7 homolog alternativeName: Transcriptional coactivator CRSP33
geneNameMED7
ARC34
CRSP9
identifierO43513
isSequenceChangedFALSE
keyword3D-structure
Activator
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameMED7
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8991391] ENSEMBL:ENSG00000155868 MED7 [Homo sapiens]
secondaryIdentifierMED7_HUMAN
sequenceLength233
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:212430] MED7 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O43513 MED7 (52872)
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