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Details on Person UniProt:P09919 CSF3
| Class:Id | ReferenceGeneProduct:52848 |
|---|---|
| _chainChangeLog | signal peptide:1-29 added on Fri February 6 2015;chain:30-207 added on Fri February 6 2015;signal peptide:1-29 for 52848 removed on Wed August 26 2020;chain:30-207 for 52848 removed on Wed August 26 2020;signal peptide:1-30 for 52848 added on Wed August 26 2020;chain:31-207 for 52848 added on Wed August 26 2020 |
| _displayName | UniProt:P09919 CSF3 |
| _timestamp | 2024-11-03 19:35:50 |
| chain | signal peptide:1-30 chain:31-207 |
| checksum | 421F635ECC776996 |
| comment | FUNCTION Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.SUBUNIT Monomer.SUBCELLULAR LOCATION O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).PHARMACEUTICAL Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood).SIMILARITY Belongs to the IL-6 superfamily.CAUTION PubMed:2420009 misquotes the gene name as 'CSF1'.ONLINE INFORMATION Clinical information on Neupogen/Granulokine |
| description | recommendedName: Granulocyte colony-stimulating factor shortName: G-CSF alternativeName: Pluripoietin innNameFilgrastim/innName innNameLenograstim/innName |
| geneName | CSF3 C17orf33 GCSF |
| identifier | P09919 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytokine Direct protein sequencing Disulfide bond Glycoprotein Growth factor Pharmaceutical Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CSF3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6785000] ENSEMBL:ENSG00000108342 CSF3 [Homo sapiens] |
| secondaryIdentifier | CSF3_HUMAN A8MXR7 |
| sequenceLength | 207 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145969] UniProt:P09919-2 CSF3 [Homo sapiens] [ReferenceIsoform:402660] UniProt:P09919-1 CSF3 [Homo sapiens] [ReferenceIsoform:8968726] UniProt:P09919-3 CSF3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5432997] CSF3 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9705721] CSF3 [endocytic vesicle lumen] [Homo sapiens] [EntityWithAccessionedSequence:9707917] CSF3 [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:9986316] CSF3 [endoplasmic reticulum lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P09919 CSF3 (52848)
