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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of p75 NTR receptor-mediated signalling

Class:IdPathwayDiagram:528077
_displayNameDiagram of p75 NTR receptor-mediated signalling
_timestamp2019-11-06 12:12:35
created[InstanceEdit:528076] Jassal, B, 2010-02-24
height1320
modified[InstanceEdit:681590] Jassal, B, 2010-05-06
[InstanceEdit:868715] Garapati, P V, 2010-06-02
[InstanceEdit:1050352] D'Eustachio, P, 2010-11-24
[InstanceEdit:1076116] D'Eustachio, P, 2010-11-26
[InstanceEdit:1447124] Jassal, B, 2011-07-13
[InstanceEdit:1489506] Rothfels, K, 2011-08-15
[InstanceEdit:1810870] Jassal, B, 2011-10-25
[InstanceEdit:3048717] Jupe, S, 2013-02-06
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8942512] Jupe, Steve, 2016-10-17
[InstanceEdit:9012759] Orlic-Milacic, Marija, 2017-07-19
[InstanceEdit:9012760] Orlic-Milacic, Marija, 2017-07-19
[InstanceEdit:9012764] Orlic-Milacic, Marija, 2017-07-19
[InstanceEdit:9012798] Orlic-Milacic, Marija, 2017-07-19
[InstanceEdit:9012803] Orlic-Milacic, Marija, 2017-07-19
[InstanceEdit:9031794] Jassal, Bijay, 2017-12-04
[InstanceEdit:9036860] Orlic-Milacic, Marija, 2018-02-09
[InstanceEdit:9638026] D'Eustachio, Peter, 2019-02-22
[InstanceEdit:9638027] D'Eustachio, Peter, 2019-02-22
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9666710] Jassal, Bijay, 2019-11-06
representedPathway[Pathway:193704] p75 NTR receptor-mediated signalling [Homo sapiens]
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id="131" reactomeId="194499" position="4156 317" bounds="4087 298 138 38" textPosition="4087 301" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NGFR:RTN4R:LINGO1:RTN4,MAG,OMG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="133" reactomeId="194481" position="4325 322" bounds="4257 296 137 52" textPosition="4257 299" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="185" reactomeId="209541" position="4690 826" bounds="4633 807 115 38" textPosition="4639 815" /> <org.gk.render.RenderableComplex id="186" reactomeId="157343" position="4416 1217" bounds="4353 1199 126 36" textPosition="4357 1200" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>gamma-secretase complex</displayName> </Properties> 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<displayName>TRAF6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="211" reactomeId="17940" position="4689 830" bounds="4598 772 182 117" textPosition="4602 846" bgColor="250 240 240" lineColor="255 153 102" insets="4608 782 162 97"> <Properties> <displayName>endosome</displayName> </Properties> <Components> <Component id="185" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.ProcessNode id="212" reactomeId="187037" position="329 161" bounds="248 126 162 71" textPosition="262 140"> <Properties> <displayName>Signaling by NTRK1 (TRKA)</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="215" reactomeId="2976673" position="382 1094" bounds="352 1083 60 22" textPosition="352 1083"> <Properties> <displayName>BCL2L11</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="216" reactomeId="113592" position="375 1181" bounds="355 1166 40 30" textPosition="359 1170"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="217" reactomeId="29370" position="651 1181" bounds="631 1166 41 30" textPosition="635 1170"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="218" reactomeId="2976671" position="655 1079" bounds="603 1068 105 22" textPosition="604 1068"> <Properties> <displayName>p-S65-BCL2L11</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1523809523809524" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="2976675" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="219" reactomeId="3006405" position="1807 440" bounds="1777 429 60 22" textPosition="1778 429"> <Properties> <displayName>ITGB3BP</displayName> </Properties> 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</org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="452" reactomeId="5665993" position="4858 321" bounds="4823 309 70 25" textPosition="4823 313" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RHOA:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="535" reactomeId="3006639" position="4745 440" bounds="4700 428 91 25" textPosition="4725 430"> <Properties> <displayName>MCF2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="537" reactomeId="167060" position="106 244" bounds="38 220 136 49" textPosition="53 230"> <Properties> <displayName>NGF processing</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="540" reactomeId="9662806" position="4749 1216" bounds="4695 1198 108 36" textPosition="4695 1199" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="139" reactomeId="193653" points="355 268, 442 298" position="442 298" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="18" points="343 309" /> <Input id="11" points="146 180" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Properties> <displayName>NGF homodimer binds to p75NTR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="140" reactomeId="193642" points="198 376, 197 413, 192 438" position="197 413" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="20" points="217 363" /> <Input id="13" points="151 351" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Properties> <displayName>Binding of pro-NGF to p75NTR:sortilin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="141" reactomeId="205075" points="479 1126, 518 1126, 561 1126" position="518 1126" lineWidth="1.0"> <Inputs> <Input id="215" points="415 1103" /> <Input id="216" stoichiometry="2" points="398 1170" /> <Input id="31" points="402 1129" /> </Inputs> <Outputs> <Output id="217" stoichiometry="2" points="628 1168" /> <Output id="28" points="627 1126" /> <Output id="218" points="633 1093" /> </Outputs> <Catalysts> <Catalyst id="63" points="518 1073" /> </Catalysts> <Properties> <displayName>JNK phosphorylates BIM, BAD and other targets</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="142" reactomeId="205136" points="462 936, 462 987, 462 1005" position="462 987" lineWidth="1.0"> <Inputs> <Input id="60" points="497 909" /> <Input id="61" stoichiometry="2" points="434 911" /> </Inputs> <Outputs> <Output id="63" points="505 1043" /> <Output id="65" stoichiometry="2" points="427 1034" /> </Outputs> <Activators> <Activator id="25" points="226 1027" /> </Activators> <Properties> <displayName>GTP-bound RAC contributes to JNK activation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="143" reactomeId="205115" points="686 340, 725 340, 756 334" position="725 340" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="17" points="569 326" /> <Input id="29" points="631 360" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> <Properties> <displayName>NGF:p75NTR complex binds to NRAGE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="144" reactomeId="193666" points="579 1049, 1954 834, 2051 817" position="1954 834" lineWidth="1.0"> <Inputs> <Input id="63" /> </Inputs> <Outputs> <Output id="32" /> </Outputs> <Properties> <displayName>Active JNK moves to the nucleus and phosphorylates different transcription factors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="145" reactomeId="204958" points="889 341, 919 341, 954 330" position="919 341" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="22" points="867 358" /> <Input id="37" points="858 334" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> <Properties> <displayName>NRAGE sequesters CHE1 in the cytoplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="205132" points="767 496, 810 496, 855 496" position="810 496" lineWidth="1.0"> <Inputs> <Input id="27" points="756 467" /> <Input id="34" stoichiometry="2" points="758 521" /> </Inputs> <Outputs> <Output id="36" stoichiometry="2" points="902 526" /> <Output id="30" points="898 472" /> </Outputs> <Catalysts> <Catalyst id="37" points="807 346" /> </Catalysts> <Properties> <displayName>NRAGE activates JNK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="147" reactomeId="205039" points="238 878, 238 916, 238 968" position="238 916" lineWidth="1.0"> <Inputs> <Input id="33" points="202 862" /> <Input id="23" points="260 863" /> </Inputs> <Outputs> <Output id="26" points="263 972" /> <Output id="25" points="196 1019" /> </Outputs> <Catalysts> <Catalyst id="24" points="287 916" /> </Catalysts> <Properties> <displayName>p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="148" reactomeId="204981" points="198 677, 185 742" position="185 742" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="39" points="188 655" /> <Input id="42" points="251 670" /> </Inputs> <Outputs> <Output id="40" /> </Outputs> <Properties> <displayName>14-3-3epsilon attentuates NADE-related apoptosis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="149" reactomeId="193650" points="396 447, 267 555, 201 612" position="267 555" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="17" points="484 346" /> <Input id="44" points="391 398" /> </Inputs> <Outputs> <Output id="39" /> </Outputs> <Properties> <displayName>p75NTR binds to NADE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="150" reactomeId="205117" points="457 572, 456 627, 456 679" position="456 627" lineWidth="1.0"> <Inputs> <Input id="43" /> </Inputs> <Outputs> <Output id="41" /> </Outputs> <Catalysts> <Catalyst id="39" points="235 631" /> </Catalysts> <Properties> <displayName>p75NTR:NADE promotes caspase2/3 activation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="151" reactomeId="205118" points="1872 495, 1871 544, 1871 588" position="1871 544" lineWidth="1.0"> <Inputs> <Input id="219" points="1820 454" /> <Input id="52" points="1926 442" /> </Inputs> <Outputs> <Output id="50" /> </Outputs> <Catalysts> <Catalyst id="46" points="1216 401, 1448 545" /> </Catalysts> <Properties> <displayName>TRAF6 polyubiquitinates NRIF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="152" reactomeId="204947" points="1892 764, 1950 747, 2045 714" position="1950 747" lineWidth="1.0"> <Inputs> <Input id="59" /> </Inputs> <Outputs> <Output id="56" /> </Outputs> <Properties> <displayName>Polyubiquitinated NRIF migrates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="193669" points="1285 343, 1334 343, 1375 337" position="1334 343" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="46" points="1234 360" /> <Input id="47" points="1245 335" /> </Inputs> <Outputs> <Output id="53" /> </Outputs> <Properties> <displayName>TRAF6 binds to p75NTR:NRIF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="154" reactomeId="204949" points="1387 407, 1429 407, 1474 408" position="1429 407" lineWidth="1.0"> <Inputs> <Input id="48" points="1374 400" /> <Input id="57" stoichiometry="2" points="1363 431" /> </Inputs> <Outputs> <Output id="58" stoichiometry="2" points="1512 436" /> <Output id="54" points="1501 401" /> </Outputs> <Catalysts> <Catalyst id="53" points="1429 356" /> </Catalysts> <Properties> <displayName>NRIF and TRAF6 may activate JNK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="155" reactomeId="205008" points="1826 659, 1826 715, 1829 755" position="1826 715" lineWidth="1.0"> <Inputs> <Input id="45" points="1786 622" /> <Input id="50" points="1857 627" /> </Inputs> <Outputs> <Output id="59" /> </Outputs> <Catalysts> <Catalyst id="45" points="1778 622, 1796 715" /> </Catalysts> <Properties> <displayName>Polyubiquitinated NRIF binds to p62 (Sequestosome)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="156" reactomeId="205112" points="1486 341, 1659 382, 1545 651" position="1659 382" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="53" /> </Inputs> <Outputs> <Output id="46" points="1211 401" /> <Output id="219" points="1793 454" /> <Output id="17" points="514 346, 631 628" /> </Outputs> <Catalysts> <Catalyst id="55" points="1656 341" /> </Catalysts> <Properties> <displayName>gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="157" reactomeId="193677" points="1180 224, 1182 261, 1181 302" position="1182 261" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="219" points="1802 426, 1747 280" /> <Input id="17" points="569 310" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> <Properties> <displayName>NRIF binds to p75NTR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="193643" points="937 1178, 966 1178, 1002 1192" position="966 1178" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="69" points="911 1193" /> <Input id="73" points="889 1159" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> <Properties> <displayName>PRDM4 (SC1) binds to p75NTR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="159" reactomeId="205056" points="2186 914, 2213 915, 2240 916" position="2213 915" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="68" points="2114 931" /> <Input id="72" points="2149 902" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> <Properties> <displayName>PRDM4 inhibits cyclin E transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="160" reactomeId="193661" points="889 1145, 1954 960, 2056 941" position="1954 960" lineWidth="1.0"> <Inputs> <Input id="73" /> </Inputs> <Outputs> <Output id="68" /> </Outputs> <Properties> <displayName>PRDM4 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="161" reactomeId="193686" points="1363 1269, 1436 1269, 1459 1241" position="1436 1269" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="79" points="1340 1165" /> <Input id="69" points="911 1230, 1143 1301" /> </Inputs> <Outputs> <Output id="90" /> </Outputs> <Properties> <displayName>p75NTR interacts with IRAK:MYD88</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="163" reactomeId="193665" points="2035 1197, 2101 1178, 2147 1178" position="2101 1178" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="84" /> </Inputs> <Outputs> <Output id="80" points="2182 1193" /> <Output id="91" points="2193 1137" /> </Outputs> <Properties> <displayName>MYD88 dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="164" reactomeId="193647" points="1565 1170, 1596 1170, 1628 1169" position="1596 1170" lineWidth="1.0"> <Inputs> <Input id="87" stoichiometry="2" points="1515 1145" /> <Input id="90" points="1529 1185" /> </Inputs> <Outputs> <Output id="78" points="1671 1186" /> <Output id="92" stoichiometry="2" points="1675 1144" /> </Outputs> <Catalysts> <Catalyst id="221" points="1595 1203" /> </Catalysts> <Properties> <displayName>IRAK is activated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="166" reactomeId="193641" points="3271 1193, 3307 1193, 3342 1197" position="3307 1193" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="85" points="3253 1130" /> <Input id="86" points="2499 1247, 2647 1312, 3229 1312" /> </Inputs> <Outputs> <Output id="89" /> </Outputs> <Properties> <displayName>IKK-beta is recruited</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="193656" points="1151 1215, 1187 1216, 1221 1216" position="1187 1216" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="81" points="1141 1185" /> <Input id="69" points="911 1226, 1105 1267" /> </Inputs> <Outputs> <Output id="82" /> </Outputs> <Properties> <displayName>p75NTR interacts with RIP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="168" reactomeId="209566" points="2547 1186, 2595 1186, 2657 1196" position="2595 1186" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="86" points="2506 1198" /> <Input id="76" points="2486 1165" /> </Inputs> <Outputs> <Output id="83" /> </Outputs> <Properties> <displayName>TRAF6 is auto-ubiquitinated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="169" reactomeId="193695" points="1827 1184, 1867 1184, 1898 1194" position="1867 1184" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="77" points="1794 1168" /> <Input id="78" points="1795 1195" /> </Inputs> <Outputs> <Output id="84" /> </Outputs> <Properties> <displayName>IRAK interacts with TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="170" reactomeId="209536" points="4008 1021, 4048 1021, 4080 1021" position="4048 1021" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="95" points="3966 1034" /> <Input id="101" points="3962 1012" /> </Inputs> <Outputs> <Output id="102" /> </Outputs> <Properties> <displayName>IkB is ubiquitinated and degraded</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="171" reactomeId="193705" points="3629 1003, 3683 1002, 3719 1001" position="3683 1002" lineWidth="1.0"> <Inputs> <Input id="96" points="3596 991" /> <Input id="99" stoichiometry="2" points="3597 1029" /> </Inputs> <Outputs> <Output id="97" points="3774 969" /> <Output id="100" stoichiometry="2" points="3777 1031" /> <Output id="101" points="3824 1001" /> </Outputs> <Catalysts> <Catalyst id="98" points="3685 1170" /> </Catalysts> <Properties> <displayName>IKKbeta phosphorylates IkB causing NF-kB to dissociate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="172" reactomeId="193691" points="3765 946, 3086 927, 3030 926" position="3086 927" lineWidth="1.0"> <Inputs> <Input id="97" /> </Inputs> <Outputs> <Output id="94" /> </Outputs> <Properties> <displayName>NF-kB migrates to the nucleus and turns on transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="173" reactomeId="193703" points="3492 1152, 3543 1151, 3591 1150" position="3543 1151" lineWidth="1.0"> <Inputs> <Input id="104" stoichiometry="4" points="3463 1130" /> <Input id="89" points="3456 1172" /> </Inputs> <Outputs> <Output id="98" points="3629 1170" /> <Output id="103" stoichiometry="4" points="3619 1125" /> </Outputs> <Catalysts> <Catalyst id="89" points="3470 1201, 3543 1195" /> </Catalysts> <Properties> <displayName>IKKbeta is activated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="174" reactomeId="193706" points="2421 427, 2472 427, 2519 427" position="2472 427" lineWidth="1.0"> <Inputs> <Input id="106" points="2403 420" /> <Input id="111" points="2394 447" /> </Inputs> <Outputs> <Output id="105" points="2546 449" /> <Output id="112" points="2547 411" /> </Outputs> <Catalysts> <Catalyst id="108" points="2469 347" /> </Catalysts> <Properties> <displayName>Production of ceramide which can activate JNK and other targets</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="175" reactomeId="193672" points="2246 260, 2312 258, 2411 298" position="2312 258" lineWidth="1.0"> <Inputs> <Input id="107" points="2084 311" /> <Input id="110" points="2192 304" /> </Inputs> <Outputs> <Output id="108" /> </Outputs> <Catalysts> <Catalyst id="109" points="2307 291" /> </Catalysts> <Properties> <displayName>Sphingomyelinase is activated by the NGF:p75NTR complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="178" reactomeId="193668" points="2868 288, 2920 287, 2953 304" position="2920 287" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="113" points="2780 314" /> <Input id="115" points="2857 315" /> </Inputs> <Outputs> <Output id="114" /> </Outputs> <Properties> <displayName>p75NTR and RHOA-GDI interact</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="179" reactomeId="193646" points="3040 268, 3085 272, 3149 295" position="3085 272" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="114" points="3001 304" /> <Input id="11" points="140 138, 321 48" /> </Inputs> <Outputs> <Output id="117" /> </Outputs> <Properties> <displayName>NGF binding to p75NTR inactivates RHOA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="181" reactomeId="194518" points="4669 325, 4747 325, 4820 322" position="4747 325" lineWidth="1.0"> <Inputs> <Input id="451" /> </Inputs> <Outputs> <Output id="452" /> </Outputs> <Catalysts> <Catalyst id="535" points="4745 425" /> </Catalysts> <Properties> <displayName>RhoA is activated by nucleotide exchange and inhibits axonal growth</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="182" reactomeId="193696" points="4364 351, 4445 402, 4465 382" position="4445 402" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="133" /> </Inputs> <Outputs> <Output id="122" points="4471 344" /> <Output id="451" points="4590 341" /> </Outputs> <Properties> <displayName>The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="183" reactomeId="193655" points="4005 281, 4084 300" position="4084 300" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="123" points="3863 314" /> <Input id="126" points="3992 308" /> </Inputs> <Outputs> <Output id="131" /> </Outputs> <Properties> <displayName>Myelin components can interact with p75NTR:NgR:LINGO1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="184" reactomeId="209573" points="3658 281, 3713 281, 3771 305" position="3713 281" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="220" points="3656 313" /> <Input id="127" points="3599 305" /> </Inputs> <Outputs> <Output id="123" /> </Outputs> <Properties> <displayName>p75NTR:NgR complex interacts with the axonal inhibitor LINGO1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="197" reactomeId="193679" points="4840 1233, 4794 1280, 4749 1280, 4695 1281" position="4749 1280" lineWidth="1.0"> <Inputs> <Input id="193" /> </Inputs> <Outputs> <Output id="190" points="4627 1281" /> <Output id="192" points="4603 1232" /> </Outputs> <Catalysts> <Catalyst id="540" points="4749 1237" /> </Catalysts> <Properties> <displayName>alpha-secretase cleaves the p75NTR extracellular domain</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="198" reactomeId="193682" points="4549 1194, 4409 1107, 4362 1107" position="4409 1107" lineWidth="1.0"> <Inputs> <Input id="192" /> </Inputs> <Outputs> <Output id="191" points="4291 1196" /> <Output id="194" points="4288 992" /> </Outputs> <Catalysts> <Catalyst id="186" points="4414 1196" /> </Catalysts> <Properties> <displayName>gamma-secretase cleaves the p75NTR transmembrane domain</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="199" reactomeId="193702" points="4218 955, 3084 665, 3046 666" position="3084 665" lineWidth="1.0"> <Inputs> <Input id="194" /> </Inputs> <Outputs> <Output id="195" /> </Outputs> <Properties> <displayName>Part of the ICD migrates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="200" reactomeId="193700" points="4356 937, 4393 937, 4421 937" position="4393 937" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="189" points="4302 892" /> <Input id="194" points="4312 955" /> <Input id="196" points="4310 928" /> </Inputs> <Outputs> <Output id="188" /> </Outputs> <Properties> <displayName>p75NTR ICD signals to NF-kB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="201" reactomeId="209532" points="4579 1194, 4660 929, 4684 848" position="4660 929" lineWidth="1.0"> <Inputs> <Input id="192" /> </Inputs> <Outputs> <Output id="185" /> </Outputs> <Properties> <displayName>The p75NTR C-terminal fragment enters endosomes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="214" interactionType="Activate" points="168 159, 245 159" position="206 159" lineWidth="2.0"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="212" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="438" reactomeId="193636" points="3472 395, 3516 397, 3553 339" position="3516 397" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="439" points="3446 342" /> <Input id="115" points="2871 343, 2948 387" /> </Inputs> <Outputs> <Output id="127" /> </Outputs> <Properties> <displayName>p75NTR interacts with the NOGO receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="442" reactomeId="193694" points="2315 1178, 2352 1179, 2378 1191" position="2352 1179" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="80" points="2283 1193" /> <Input id="74" points="2284 1171" /> </Inputs> <Outputs> <Output id="86" /> </Outputs> <Properties> <displayName>p62 is recruited and forms a complex with TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="450" reactomeId="193684" points="2915 1293, 2975 1292, 3073 1239" position="2975 1292" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="93" points="2886 1190" /> <Input id="86" points="2506 1226" /> </Inputs> <Outputs> <Output id="75" /> </Outputs> <Properties> <displayName>p62 recruits an atypical PKC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="501" reactomeId="9012761" points="4007 426, 4234 436, 4304 351" position="4234 436" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="131" points="4130 339" /> <Input id="113" points="2769 349, 3006 450" /> </Inputs> <Outputs> <Output id="133" /> </Outputs> <Properties> <displayName>The p75NTR:NgR:MDGI binds RHOA-GDI</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="536" points="4697 440, 4455 445, 3290 1033, 1512 1089, 1454 839, 332 841, 318 900" position="1512 1089" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="535" /> </Inputs> <Outputs> <Output id="24" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableInteraction id="538" interactionType="Activate" points="105 217, 105 180" position="105 198" lineWidth="2.0"> <Inputs> <Input id="537" /> </Inputs> <Outputs> <Output id="11" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="539" interactionType="Activate" points="105 272, 105 303" position="105 287" lineWidth="2.0"> <Inputs> <Input id="537" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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