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Details on Person UniProt:P13385 CRIPTO
| Class:Id | ReferenceGeneProduct:52798 |
|---|---|
| _chainChangeLog | signal peptide:1-30 added on Fri February 6 2015;chain:31-150 added on Fri February 6 2015;propeptide:151-188 added on Fri February 6 2015 |
| _displayName | UniProt:P13385 CRIPTO |
| _timestamp | 2026-02-20 23:00:57 |
| chain | signal peptide:1-30 chain:31-150 propeptide:151-188 |
| checksum | AEE8727D0F27D886 |
| comment | FUNCTION GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).SUBUNIT Interacts with the activin type-1 receptor ACVR1B.SUBCELLULAR LOCATION Released from the cell membrane by GPI cleavage.TISSUE SPECIFICITY Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.PTM The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form.SIMILARITY Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. |
| description | recommendedName: fullName evidence="12"Protein Cripto alternativeName: fullName evidence="13"Cripto, EGF-CFC family member alternativeName: Cripto-1 growth factor shortName: CRGF alternativeName: Epidermal growth factor-like cripto protein CR1 alternativeName: Teratocarcinoma-derived growth factor 1 |
| geneName | CRIPTO CRIPTO-1 TDGF1 |
| identifier | P13385 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein GPI-anchor Growth factor Lipoprotein Membrane Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CRIPTO |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2888887] ENSEMBL:ENSG00000241186 CRIPTO [Homo sapiens] |
| secondaryIdentifier | TDGF1_HUMAN Q8TCC1 |
| sequenceLength | 188 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:452300] N-aspartyl-glycosylphosphatidylinositolethanolamine-TDGF1(31-188) [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:1226042] N-aspartyl-glycosylphosphatidylinositolethanolamine at 150 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P13385 CRIPTO (52798)
