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Details on Person 3-methyl-2-oxobutanoate+acetyl-CoA+H2O->H++(2S)-2-isopropylmalate+coenzyme A

Class:Id	Reaction:5268272
_displayName	3-methyl-2-oxobutanoate+acetyl-CoA+H2O->H++(2S)-2-isopropylmalate+coenzyme A
_doRelease	FALSE
_timestamp	2018-04-06 21:39:23
catalystActivity	[CatalystActivity:5264178] 2-isopropylmalate synthase activity of 2-isopropylmalate synthase [cytoplasm]
catalystActivityReference	[CatalystActivityReference:9643839] 2-isopropylmalate synthase activity of 2-isopropylmalate synthase [cytoplasm] Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine
compartment	[Compartment:459] cytoplasm
created	[InstanceEdit:5323153] Preece, Justin, 2014-02-14
crossReference	[DatabaseIdentifier:5289839] AraCyc:2-ISOPROPYLMALATESYN-RXN [DatabaseIdentifier:5289835] PIR:T29059 [DatabaseIdentifier:5289836] PIR:S52294 [DatabaseIdentifier:5289837] PIR:S35132 [DatabaseIdentifier:5289838] PIR:S08431 [DatabaseIdentifier:5289844] PIR:I40725 [DatabaseIdentifier:5289845] PIR:H69649 [DatabaseIdentifier:5289846] PIR:G64473 [DatabaseIdentifier:5289847] PIR:G64362 [DatabaseIdentifier:5289840] PIR:E64106 [DatabaseIdentifier:5289841] PIR:C81895 [DatabaseIdentifier:5289842] PIR:C81270 [DatabaseIdentifier:5289843] PIR:B70479 [DatabaseIdentifier:5289867] PIR:B64729 [DatabaseIdentifier:5289866] PIR:B64449 [DatabaseIdentifier:5289865] PIR:A23872 [DatabaseIdentifier:5304914] EC-NUMBER:2.3.3.13
input	[SimpleEntity:5279680] 3-methyl-2-oxobutanoate [cytoplasm] [SimpleEntity:1131337] Ac-CoA [cytoplasm] [SimpleEntity:5278291] H2O [cytoplasm]
modified	[InstanceEdit:5679620] Amarasinghe, Vindhya, 2015-03-04 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9605079] D'Eustachio, Peter, 2018-04-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9753508] Wu, Guanming, 2021-09-08
name	3-methyl-2-oxobutanoate+acetyl-CoA+H2O->H++(2S)-2-isopropylmalate+coenzyme A 2-ISOPROPYLMALATESYN-RXN Alpha-isopropylmalate synthase Alpha-IPM synthetase α-IPM synthase biochemicalReaction36947
output	[SimpleEntity:1132304] H+ [cytoplasm] [SimpleEntity:5279367] (2S)-2-isopropylmalate [cytoplasm] [SimpleEntity:1131323] CoA-SH [cytoplasm]
precedingEvent	[Reaction:5268273] 2,3-dihydroxy-3-methylbutanoate->3-methyl-2-oxobutanoate+H2O [Arabidopsis thaliana] [Reaction:5268650] ketol-acid reductoisomerase [Arabidopsis thaliana] [Reaction:5268650] ketol-acid reductoisomerase [Arabidopsis thaliana] [Reaction:5268650] ketol-acid reductoisomerase [Arabidopsis thaliana]
regulatedBy	[NegativeRegulation:5263836] Negative regulation by 'L-leucine [cytoplasm]' [NegativeRegulation:5679629] Negative regulation by 'L-leucine [cytoplasm]'
regulationReference	[RegulationReference:9641978] Negative regulation by 'L-leucine [cytoplasm]' Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine
revised	[InstanceEdit:5679627] Amarasinghe, Vindhya, 2015-01-15
species	[Species:170905] Arabidopsis thaliana
stableIdentifier	[StableIdentifier:8908104] R-ATH-5268272.1
summation	[Summation:5679621] Four genes are postulated for the conversion of 3-methyl-2-... [Summation:5679631] Leucine feedback of isopropylmalate synthase
(hasEvent)	[Pathway:5267639] leucine biosynthesis [Arabidopsis thaliana] [Pathway:5268148] superpathway of leucine, valine, and isoleucine biosynthesis [Arabidopsis thaliana]
(precedingEvent)	[Reaction:5268274] (2S)-2-isopropylmalate->2-isopropylmaleate+H2O [Arabidopsis thaliana]
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No pathways have been reviewed or authored by 3-methyl-2-oxobutanoate+acetyl-CoA+H2O->H++(2S)-2-isopropylmalate+coenzyme A (5268272)