Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The key compound of the 5-deoxy(iso)flavonoid pathway, the t...
| Class:Id | Summation:5266949 |
|---|---|
| _displayName | The key compound of the 5-deoxy(iso)flavonoid pathway, the t... |
| _timestamp | 2014-02-14 21:43:34 |
| created | [InstanceEdit:5323153] Preece, Justin, 2014-02-14 |
| text | The key compound of the 5-deoxy(iso)flavonoid pathway, the trihydroxychalcone isoliquiritigenin is synthesized by the coaction of chalcone synthase and polyketide (chalcone) reductase from 4-coumaryl-CoA and malonyl-CoA. Polyketide reductase is the enzyme responsible to redirect the flavonoid pathway into 5-deoxyflavonoid production, which is unique for leguminous plants. The reduction does occur prior to the formation of the chalcone, most likely at the level of a polyketide intermediate. Both enzymes are coordinately induced by elicitors, highlighting the importance of this pathway for plant defense mechanisms. The introduction of polyketide reductase in non-leguminous plants trigger the production of isoflavonoid-derived phytoalexins, underlining the key role of this particular enzyme in the 5-deoxyflavonoid pathway. |
| (summation) | [Reaction:5269529] H++4-coumaroyl-CoA+malonyl-CoA+NADPH->isoliquiritigenin+coenzyme A+CO2+NADP++H2O [Arabidopsis thaliana] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The key compound of the 5-deoxy(iso)flavonoid pathway, the t... (5266949)
