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Details on Person ATP-citrate lyase (ACL) catalyzes the ATP- and CoA-dependent...
| Class:Id | Summation:5266817 |
|---|---|
| _displayName | ATP-citrate lyase (ACL) catalyzes the ATP- and CoA-dependent... |
| _timestamp | 2014-02-14 21:43:34 |
| created | [InstanceEdit:5323153] Preece, Justin, 2014-02-14 |
| text | ATP-citrate lyase (ACL) catalyzes the ATP- and CoA-dependent cleavage of citrate to form acetyl-CoA and oxaloacetate. In the plant cell cytosol, acetyl-CoA generated in this reaction acts as precursor for the biosynthesis of very long chain fatty acids and many secondary metabolites including flavonoids and terpenoids. In vertebrates, acetyl-CoA generated from citrate feeds into de novo fatty acid biosynthesis and cholesterol biosynthesis. In Arabidopsis, ACL is a heterooctomer of two subunits, ACLA and ACLB. The ACLA subunit is encoded by three genes, and the ACLB subunit is encoded by two genes. The enzyme activity of Arabidopsis ACL was confirmed by heterologous expressing of ACLA-1 and ACLB-2 in yeast where the activity was detected only in the strain co-expressing the two subunits, not in strains expressing the subunits individually. |
| (summation) | [Complex:5280077] CPLX-7089 [cytoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by ATP-citrate lyase (ACL) catalyzes the ATP- and CoA-dependent... (5266817)
