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Details on Person STING complex

Class:Id	GO_CellularComponent:5263522
_displayName	STING complex
_timestamp	2015-08-21 20:02:24
accession	1990231
componentOf	[Compartment:437051] cytoplasmic vesicle membrane [GO_CellularComponent:171334] cytoplasmic vesicle [Compartment:459] cytoplasm [GO_CellularComponent:354] intracellular anatomical structure
created	[InstanceEdit:5263134] Weiser, JD
definition	A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response.
instanceOf	[GO_CellularComponent:6791903] membrane protein complex [GO_CellularComponent:258170] protein-containing complex [GO_CellularComponent:357] cellular_component
modified	[InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689214] Cook, Justin, 2020-05-15 [InstanceEdit:9715950] Shorser, Solomon, 2021-02-17 [InstanceEdit:9730069] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750511] Weiser, JD, 2021-08-11 [InstanceEdit:9758049] Weiser, JD, 2021-11-08 [InstanceEdit:9767446] Wright, Adam, 2022-02-25 [InstanceEdit:9773560] Weiser, Joel, 2022-05-04 [InstanceEdit:9909909] Weiser, Joel, 2024-05-14 [InstanceEdit:9910546] Weiser, Joel, 2024-05-14 [InstanceEdit:9917761] Weiser, Joel, 2024-08-09 [InstanceEdit:9926777] Weiser, Joel, 2024-11-03 [InstanceEdit:9939260] Weiser, Joel, 2025-02-21 [InstanceEdit:9948590] Weiser, Joel, 2025-05-21 [InstanceEdit:9963890] Weiser, Joel, 2025-08-15 [InstanceEdit:9970828] Weiser, Joel, 2025-10-31 [InstanceEdit:9983368] Weiser, Joel, 2026-02-22 [InstanceEdit:9989188] Weiser, Joel, 2026-05-15
name	STING complex
referenceDatabase	[ReferenceDatabase:1] GO
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No pathways have been reviewed or authored by STING complex (5263522)