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Details on Person IKK complex with defective NEMO (IKBKG) does not phosphorylate IkB within IkB:NF-kappaB (via TNFR)

Class:Id	FailedReaction:5262865
_displayName	IKK complex with defective NEMO (IKBKG) does not phosphorylate IkB within IkB:NF-kappaB (via TNFR)
_doRelease	FALSE
_timestamp	2022-08-31 05:50:39
catalystActivity	[CatalystActivity:5262949] protein serine/threonine kinase activity of TNFalpha associated IKBKG variants [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5262932] Shamovsky, V, 2014-02-09
disease	[Disease:5228860] primary immunodeficiency disease
entityFunctionalStatus	[EntityFunctionalStatus:5262890] partial_loss_of_function of TNFalpha associated IKBKG variants [cytosol]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:168130] NFkB inhibitor:NFkB complex [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9815980] Shamovsky, Veronica, 2022-08-31
name	IKK complex with defective NEMO (IKBKG) does not phosphorylate IkB within IkB:NF-kappaB (via TNFR)
normalReaction	[Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8915727] R-HSA-5262865.1
summation	[Summation:9815981] IKBKG is encoded by an X-linked gene. Null alleles of the ge...
(hasEvent)	[Pathway:5603026] NEMO deficiency (via TNFR) [Homo sapiens] [Pathway:9815942] Defective TNF signaling [Homo sapiens]
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No pathways have been reviewed or authored by IKK complex with defective NEMO (IKBKG) does not phosphorylate IkB within IkB:NF-kappaB (via TNFR) (5262865)