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Details on Person UniProt:P04798 CYP1A1

Class:IdReferenceGeneProduct:52624
_chainChangeLogchain:1-512 added on Sat February 7 2015
_displayNameUniProt:P04798 CYP1A1
_timestamp2025-02-21 20:07:45
chainchain:1-512
checksum3C62366044148EFD
commentFUNCTION A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).CATALYTIC ACTIVITY an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY estrone + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY estrone + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY estrone + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY estrone + reduced [NADPH--hemoprotein reductase] + O2 = 15alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY estrone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY 17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-17beta-estradiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY 17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxy-17beta-estradiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY 17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxy-17beta-estradiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY 17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxy-17beta-estradiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY 17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 15alpha-hydroxy-17beta-estradiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z)-eicosatrienoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY all-trans-retinol + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-retinal + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)CATALYTIC ACTIVITY all-trans-retinal + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-retinoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)CATALYTIC ACTIVITY (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2OCATALYTIC ACTIVITY (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2OCATALYTIC ACTIVITY (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2OCOFACTOR Steroid hormone biosynthesis.PATHWAY Lipid metabolism; fatty acid metabolism.PATHWAY Cofactor metabolism; retinol metabolism.SUBUNIT Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.INTERACTION Lung, lymphocytes and placenta.INDUCTION By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).SIMILARITY Belongs to the cytochrome P450 family.ONLINE INFORMATION CYP1A1 allelesONLINE INFORMATION CYP1A1 entry
descriptionrecommendedName: fullName evidence="24"Cytochrome P450 1A1 shortName evidence="23"CYPIA1 ecNumber evidence="7 9 13 16"1.14.14.1 alternativeName: Cytochrome P450 form 6 alternativeName: Cytochrome P450-C alternativeName: Cytochrome P450-P1 alternativeName: fullName evidence="36"Hydroperoxy icosatetraenoate dehydratase ecNumber evidence="19"4.2.1.152
geneNameCYP1A1
identifierP04798
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Cytoplasm
Endoplasmic reticulum
Fatty acid metabolism
Glycoprotein
Heme
Iron
Lipid biosynthesis
Lipid metabolism
Lyase
Membrane
Metal-binding
Microsome
Mitochondrion
Mitochondrion inner membrane
Monooxygenase
Oxidoreductase
Proteomics identification
Reference proteome
Steroid biosynthesis
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
nameCYP1A1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:5649915] ENSEMBL:ENSG00000140465 CYP1A1 [Homo sapiens]
secondaryIdentifierCP1A1_HUMAN
A4F3V9
A4F3W0
Q53G18
sequenceLength512
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:8976946] UniProt:P04798-1 CYP1A1 [Homo sapiens]
[ReferenceIsoform:8976947] UniProt:P04798-2 CYP1A1 [Homo sapiens]
[ReferenceIsoform:8976948] UniProt:P04798-3 CYP1A1 [Homo sapiens]
(referenceEntity)[EntityWithAccessionedSequence:52623] CYP1A1 [endoplasmic reticulum membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P04798 CYP1A1 (52624)
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