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Details on Person UniProt:P15954 COX7C
| Class:Id | ReferenceGeneProduct:52610 |
|---|---|
| _chainChangeLog | transit peptide:1-16 added on Sat February 7 2015;chain:17-63 added on Sat February 7 2015 |
| _displayName | UniProt:P15954 COX7C |
| _timestamp | 2026-02-20 22:20:20 |
| chain | transit peptide:1-16 chain:17-63 |
| checksum | A7DF0F4BAF39FB28 |
| comment | FUNCTION Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.PATHWAY Energy metabolism; oxidative phosphorylation.SUBUNIT Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and COXFA4, which are encoded in the nuclear genome (PubMed:30030519). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695). Interacts with RAB5IF (PubMed:31536960).INTERACTION Belongs to the cytochrome c oxidase VIIc family. |
| description | recommendedName: Cytochrome c oxidase subunit 7C, mitochondrial alternativeName: Cytochrome c oxidase polypeptide VIIc |
| geneName | COX7C |
| identifier | P15954 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Membrane Mitochondrion Mitochondrion inner membrane Proteomics identification Reference proteome Transit peptide Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | COX7C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991203] ENSEMBL:ENSG00000127184 COX7C [Homo sapiens] |
| secondaryIdentifier | COX7C_HUMAN Q6NR81 |
| sequenceLength | 63 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:164306] COX7C [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P15954 COX7C (52610)
