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Details on Person UniProt:Q3T1H5 Tdp2
| Class:Id | ReferenceGeneProduct:525889 |
|---|---|
| _chainChangeLog | chain:1-366 added on Fri February 6 2015 |
| _displayName | UniProt:Q3T1H5 Tdp2 |
| _timestamp | 2025-05-21 21:27:50 |
| chain | chain:1-366 |
| checksum | D64F045D2FF80E9A |
| comment | FUNCTION DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress.COFACTOR Binds 1 magnesium or manganese ion per subunit.SUBUNIT Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4.SUBCELLULAR LOCATION Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein.PTM Ubiquitinated by TRAF6.SIMILARITY Belongs to the CCR4/nocturin family. |
| created | [InstanceEdit:525883] Kanapin, AA |
| description | recommendedName: Tyrosyl-DNA phosphodiesterase 2 shortName: Tyr-DNA phosphodiesterase 2 ecNumber evidence="2"3.1.4.- alternativeName: 5'-tyrosyl-DNA phosphodiesterase shortName: 5'-Tyr-DNA phosphodiesterase alternativeName: TRAF and TNF receptor-associated protein |
| geneName | Tdp2 Ttrap |
| identifier | Q3T1H5 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cytoplasm DNA damage DNA repair Hydrolase Isopeptide bond Magnesium Metal-binding Nuclease Nucleus Phosphoprotein Reference proteome Ubl conjugation |
| modified | [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | Tdp2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TYDP2_RAT |
| sequenceLength | 366 |
| species | [Species:48895] Rattus norvegicus |
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No pathways have been reviewed or authored by UniProt:Q3T1H5 Tdp2 (525889)
