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Details on Person UniProt:P04118 CLPS
| Class:Id | ReferenceGeneProduct:52532 |
|---|---|
| _chainChangeLog | signal peptide:1-17 added on Fri February 6 2015;propeptide:18-22 added on Fri February 6 2015;chain:23-112 added on Fri February 6 2015 |
| _displayName | UniProt:P04118 CLPS |
| _timestamp | 2024-11-03 20:18:29 |
| chain | signal peptide:1-17 propeptide:18-22 chain:23-112 |
| checksum | 772872EBBE7C4DF8 |
| comment | FUNCTION Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.FUNCTION Enterostatin has a biological activity as a satiety signal.SUBUNIT Forms a 1:1 stoichiometric complex with pancreatic lipase.SUBCELLULAR LOCATION Expressed by the pancreas.POLYMORPHISM Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.SIMILARITY Belongs to the colipase family.ONLINE INFORMATION Colipase entry |
| description | recommendedName: fullName evidence="7"Colipase |
| geneName | CLPS |
| identifier | P04118 |
| isSequenceChanged | FALSE |
| keyword | Diabetes mellitus Digestion Direct protein sequencing Disulfide bond Lipid degradation Lipid metabolism Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CLPS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004046] ENSEMBL:ENSG00000137392 CLPS [Homo sapiens] |
| secondaryIdentifier | COL_HUMAN Q5T9G7 Q5U809 |
| sequenceLength | 112 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:192469] CLPS [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P04118 CLPS (52532)
