Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person botG:SYT1:GT1b [plasma membrane]

Class:Id	Complex:5250975
_displayName	botG:SYT1:GT1b [plasma membrane]
_timestamp	2020-10-08 22:01:14
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5250954] D'Eustachio, Peter, 2014-01-31
disease	[Disease:3632909] botulism
goCellularComponent	[GO_CellularComponent:6485] host cell plasma membrane
hasComponent	[Complex:5250990] BoNT/G HC:LC dimer [plasma membrane] [Clostridium botulinum] [EntityWithAccessionedSequence:181499] BoNT/G HC disulfide bonded [plasma membrane] [Clostridium botulinum] [Complex:190050] BoNT/G LC:Zn2+ disulfide bonded [plasma membrane] [Clostridium botulinum] [EntityWithAccessionedSequence:181505] BoNT/G LC disulfide bonded [plasma membrane] [Clostridium botulinum] [SimpleEntity:109265] Zn2+ [plasma membrane] [SimpleEntity:5244403] GT1b [plasma membrane] [EntityWithAccessionedSequence:168786] SYT1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5250969] Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins [LiteratureReference:5250974] Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity
modified	[InstanceEdit:5251019] D'Eustachio, Peter, 2014-01-31 [InstanceEdit:8959586] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
name	botG:SYT1:GT1b BoNT/G:SYT1:GT1b
relatedSpecies	[Species:168825] Clostridium botulinum
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5646392] R-HSA-5250975.21
(input)	[BlackBoxEvent:5250979] botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane [Homo sapiens]
(output)	[Reaction:5250986] botG HC:LC binds SYT1 and GT1b on the target cell surface [Homo sapiens]
(replacementInstances)	[_Deleted:5251026] Deletion of instance: 181532
(updatedInstance)	[_UpdateTracker:9896770] Update Tracker - [Complex:5250975] botG:SYT1:GT1b [plasma membrane] - v60:[removeSpecies] [_UpdateTracker:9901858] Update Tracker - [Complex:5250975] botG:SYT1:GT1b [plasma membrane] - v75:[addName]
[Change default viewing format]

No pathways have been reviewed or authored by botG:SYT1:GT1b [plasma membrane] (5250975)