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Details on Person botG LC cleaves target cell VAMP2

Class:Id	Reaction:5250962
_displayName	botG LC cleaves target cell VAMP2
_doRelease	TRUE
_timestamp	2020-10-08 22:01:14
authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity	[CatalystActivity:5250956] metalloendopeptidase activity of botG LC:Zn2+ [cytosol]
catalystActivityReference	[CatalystActivityReference:9643381] metalloendopeptidase activity of BoNT/G LC:Zn2+ [cytosol] Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond
compartment	[Compartment:201753] synaptic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:5250954] D'Eustachio, Peter, 2014-01-31
disease	[Disease:3632909] botulism
input	[EntityWithAccessionedSequence:181517] VAMP2 [synaptic vesicle membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5250965] Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond [LiteratureReference:5263580] Membrane fusion machinery: insights from synaptic proteins [LiteratureReference:379281] The synaptic vesicle cycle [LiteratureReference:5250988] Botulinum neurotoxin type G proteolyses the Ala81-Ala82 bond of rat synaptobrevin 2
modified	[InstanceEdit:5251019] D'Eustachio, Peter, 2014-01-31 [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5333086] D'Eustachio, Peter, 2014-02-18 [InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botG LC cleaves target cell VAMP2
output	[EntityWithAccessionedSequence:5250970] VAMP2(2-81) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5250961] VAMP2(82-116) [synaptic vesicle membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5250972] botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol [Homo sapiens] [BlackBoxEvent:5250979] botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane [Homo sapiens]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644619] R-HSA-5250962.5
summation	[Summation:5263587] Botulinum toxin type G light chain (botG LC), in the cytosol...
(hasEvent)	[Pathway:5250989] Toxicity of botulinum toxin type G (botG) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776517] Update Tracker - [Reaction:5250962] botG LC cleaves target cell VAMP2 - v75:[modifyText] [_UpdateTracker:9786147] Update Tracker - [Reaction:5250962] botG LC cleaves target cell VAMP2 - v50:[modifyText]
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No pathways have been reviewed or authored by botG LC cleaves target cell VAMP2 (5250962)