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Details on Person botF LC cleaves target cell VAMP2

Class:Id	Reaction:5250892
_displayName	botF LC cleaves target cell VAMP2
_doRelease	TRUE
_timestamp	2020-10-08 22:01:07
authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity	[CatalystActivity:194817] metalloendopeptidase activity of botF LC:Zn2+ [cytosol]
catalystActivityReference	[CatalystActivityReference:9643353] metalloendopeptidase activity of BoNT/F LC:Zn2+ [cytosol] Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin
compartment	[Compartment:201753] synaptic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:5250893] D'Eustachio, Peter, 2014-01-30
disease	[Disease:3632909] botulism
edited	[InstanceEdit:181692] Gopinathrao, G, 2006-06-15 22:12:29
input	[EntityWithAccessionedSequence:181517] VAMP2 [synaptic vesicle membrane] [Homo sapiens]
literatureReference	[LiteratureReference:5263580] Membrane fusion machinery: insights from synaptic proteins [LiteratureReference:379281] The synaptic vesicle cycle [LiteratureReference:181778] Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin
modified	[InstanceEdit:194837] Gopinathrao, G, 2007-03-29 10:41:15 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197013] Gopinathrao, G, 2007-04-30 09:21:41 [InstanceEdit:200989] Gopinathrao, G, 2007-07-27 15:43:30 [InstanceEdit:201181] Gopinathrao, G, 2007-08-01 20:04:38 [InstanceEdit:201316] Gopinathrao, G, 2007-08-03 18:19:30 [InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29 [InstanceEdit:2648976] D'Eustachio, P, 2012-11-21 [InstanceEdit:2660809] D'Eustachio, P, 2012-11-23 [InstanceEdit:3632911] Gillespie, ME, 2013-05-28 [InstanceEdit:5228354] D'Eustachio, Peter, 2014-01-10 [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botF LC cleaves target cell VAMP2
output	[EntityWithAccessionedSequence:194815] VAMP2(2-58) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5250891] VAMP2(59-116) [synaptic vesicle membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5250884] botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol [Homo sapiens] [BlackBoxEvent:5250875] botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane [Homo sapiens]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2007-08-21
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644709] R-HSA-5250892.4
summation	[Summation:5263570] Botulinum toxin type F light chain (botF LC), in the cytosol...
(hasEvent)	[Pathway:5250981] Toxicity of botulinum toxin type F (botF) [Homo sapiens]
(replacementInstances)	[_Deleted:5250998] Deletion of instance: 168769
(updatedInstance)	[_UpdateTracker:9776575] Update Tracker - [Reaction:5250892] botF LC cleaves target cell VAMP2 - v75:[modifyText] [_UpdateTracker:9786237] Update Tracker - [Reaction:5250892] botF LC cleaves target cell VAMP2 - v50:[modifyText]
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No pathways have been reviewed or authored by botF LC cleaves target cell VAMP2 (5250892)