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Details on Person botF HC:LC binds SV2A or B or C and GT1b on the target cell surface

Class:Id	Reaction:5250880
_displayName	botF HC:LC binds SV2A or B or C and GT1b on the target cell surface
_doRelease	TRUE
_timestamp	2020-10-08 22:01:05
authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5250886] D'Eustachio, Peter, 2014-01-30
disease	[Disease:3632909] botulism
input	[Complex:5250693] botF HC:LC dimer [extracellular region] [Clostridium botulinum] [SimpleEntity:5244403] GT1b [plasma membrane] [DefinedSet:5324684] SV2A,B,C [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5250882] Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F [LiteratureReference:5244438] Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
modified	[InstanceEdit:5250893] D'Eustachio, Peter, 2014-01-30 [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5324692] D'Eustachio, Peter, 2014-02-17 [InstanceEdit:5333086] D'Eustachio, Peter, 2014-02-18 [InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botF HC:LC binds SV2A or B or C and GT1b on the target cell surface
output	[Complex:5250879] botF:SV2:GT1b [plasma membrane] [Homo sapiens]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644721] R-HSA-5250880.4
summation	[Summation:5263583] The botulinum toxin type F disulfide-bonded heavy chain - li...
(hasEvent)	[Pathway:5250981] Toxicity of botulinum toxin type F (botF) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5250875] botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane [Homo sapiens]
(replacementInstances)	[_Deleted:5251022] Deletion of instance: 181359
(updatedInstance)	[_UpdateTracker:9776588] Update Tracker - [Reaction:5250880] botF HC:LC binds SV2A or B or C and GT1b on the target cell surface - v75:[modifyText] [_UpdateTracker:9786211] Update Tracker - [Reaction:5250880] botF HC:LC binds SV2A or B or C and GT1b on the target cell surface - v50:[modifyText]
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No pathways have been reviewed or authored by botF HC:LC binds SV2A or B or C and GT1b on the target cell surface (5250880)