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Details on Person botF:SV2:GT1b [plasma membrane]

Class:Id	Complex:5250879
_displayName	botF:SV2:GT1b [plasma membrane]
_timestamp	2020-10-08 22:01:09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5250886] D'Eustachio, Peter, 2014-01-30
disease	[Disease:3632909] botulism
goCellularComponent	[GO_CellularComponent:6485] host cell plasma membrane
hasComponent	[Complex:5250874] BoNT/F HC:LC dimer [plasma membrane] [Clostridium botulinum] [EntityWithAccessionedSequence:181455] botF HC disulfide bonded [plasma membrane] [Clostridium botulinum] [Complex:190025] BoNT/F LC:Zn2+ disulfide bonded [plasma membrane] [Clostridium botulinum] [EntityWithAccessionedSequence:181490] botF LC disulfide bonded [plasma membrane] [Clostridium botulinum] [SimpleEntity:109265] Zn2+ [plasma membrane] [SimpleEntity:5244403] GT1b [plasma membrane] [DefinedSet:5324684] SV2A,B,C [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5250882] Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F [LiteratureReference:181778] Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin
modified	[InstanceEdit:5250893] D'Eustachio, Peter, 2014-01-30 [InstanceEdit:5324692] D'Eustachio, Peter, 2014-02-17 [InstanceEdit:8959586] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
name	botF:SV2:GT1b BoNT/F:SV2:GT1b
relatedSpecies	[Species:168825] Clostridium botulinum
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5648602] R-HSA-5250879.21
(input)	[BlackBoxEvent:5250875] botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane [Homo sapiens]
(output)	[Reaction:5250880] botF HC:LC binds SV2A or B or C and GT1b on the target cell surface [Homo sapiens]
(replacementInstances)	[_Deleted:5251026] Deletion of instance: 181532
(updatedInstance)	[_UpdateTracker:9895973] Update Tracker - [Complex:5250879] botF:SV2:GT1b [plasma membrane] - v60:[removeSpecies] [_UpdateTracker:9901870] Update Tracker - [Complex:5250879] botF:SV2:GT1b [plasma membrane] - v75:[addName]
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No pathways have been reviewed or authored by botF:SV2:GT1b [plasma membrane] (5250879)