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Details on Person SLC1A1 exchanges L-Glu, H+ and 3Na+ for K+

Class:Id	Reaction:5250230
_displayName	SLC1A1 exchanges L-Glu, H+ and 3Na+ for K+
_doRelease	FALSE
_timestamp	2016-07-15 23:48:57
authored	[InstanceEdit:5250224] Jassal, Bijay, 2014-01-24
catalystActivity	[CatalystActivity:5250237] high-affinity L-glutamate transmembrane transporter activity of SLC1A1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5250224] Jassal, Bijay, 2014-01-24
edited	[InstanceEdit:5250224] Jassal, Bijay, 2014-01-24
inferredFrom	[Reaction:5250226] Eaac1 exchanges L-Glu, H+ and 3Na+ for K+ [Rattus norvegicus]
input	[SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:29804] K+ [cytosol] [SimpleEntity:210382] L-Glu [extracellular region]
literatureReference	[LiteratureReference:428029] Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain [LiteratureReference:428025] Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex [LiteratureReference:427990] Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures [LiteratureReference:5250235] Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18
modified	[InstanceEdit:428053] Jassal, Bijay, 2009-06-30 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:5250532] Jassal, Bijay, 2014-01-27 [InstanceEdit:5357507] Jassal, Bijay, 2014-03-21 [InstanceEdit:5367033] Jassal, Bijay, 2014-04-25 [InstanceEdit:5673780] Jassal, Bijay, 2015-02-10 [InstanceEdit:5674209] Jassal, Bijay, 2015-02-11 [InstanceEdit:5674394] Jassal, Bijay, 2015-02-12 [InstanceEdit:6792859] Jassal, Bijay, 2015-08-28 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19
name	SLC1A1 exchanges L-Glu, H+ and 3Na+ for K+
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:74126] K+ [extracellular region] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:29404] L-Glu [cytosol]
regulatedBy	[NegativeRegulation:5255396] Negative regulation by 'ARL6IP5 [cytosol]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8881451] R-HSA-5250230.1
summation	[Summation:5250203] There are two classes of glutamate transporters; the excitat...
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