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Details on Person UniProt:Q13085-1 ACACA
| Class:Id | ReferenceIsoform:52492 |
|---|---|
| _chainChangeLog | chain:1-2346 added on Sat February 7 2015 |
| _displayName | UniProt:Q13085-1 ACACA |
| _timestamp | 2025-02-21 18:43:58 |
| chain | chain:1-2346 |
| checksum | F1F0A518F8824FFC |
| comment | FUNCTION Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443).CATALYTIC ACTIVITY hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)COFACTOR Binds 2 magnesium or manganese ions per subunit.COFACTOR Inhibited by phosphorylation (PubMed:16326698, PubMed:29899443). Citrate promotes oligomerization of the protein into filaments that correspond to the most active form of the carboxylase (PubMed:29899443). Inhibited by palmitoyl-CoA (PubMed:29899443).PATHWAY Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.SUBUNIT Monomer, homodimer, and homotetramer (PubMed:20952656, PubMed:29899443). Can form filamentous polymers (PubMed:20457939, PubMed:20952656, PubMed:29899443). Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis (PubMed:12360400, PubMed:16326698, PubMed:18452305, PubMed:29899443). Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity (PubMed:20457939).INTERACTION Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.DOMAIN Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the ATP-dependent transient carboxylation of the biotin covalently attached to the central biotinyl-binding/biotin carboxyl carrier (BCC) domain (Probable). The C-terminal carboxyl transferase (CT) domain catalyzes the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA to produce malonyl-CoA (Probable).PTM Phosphorylation on Ser-1263 is required for interaction with BRCA1.PTM Phosphorylation at Ser-80 by AMPK inactivates enzyme activity.PTM The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION Acetyl-CoA carboxylase entry |
| description | recommendedName: fullName evidence="21"Acetyl-CoA carboxylase 1 shortName: ACC1 ecNumber evidence="16 17 18"6.4.1.2 alternativeName: Acetyl-Coenzyme A carboxylase alpha shortName: ACC-alpha |
| geneName | ACACA ACAC ACC1 ACCA |
| identifier | Q13085 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Allosteric enzyme Alternative promoter usage ATP-binding Biotin Cytoplasm Direct protein sequencing Fatty acid biosynthesis Fatty acid metabolism Ligase Lipid biosynthesis Lipid metabolism Magnesium Manganese Metal-binding Multifunctional enzyme Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:200562] Gopinathrao, G, 2007-07-20 19:34:32 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ACACA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004520] ENSEMBL:ENSG00000278540 ACACA [Homo sapiens] |
| secondaryIdentifier | ACACA_HUMAN B2RP68 B2ZZ90 Q6KEV6 Q6XDA8 Q7Z2G8 Q7Z561 Q7Z563 Q7Z564 Q86WB2 Q86WB3 |
| sequenceLength | 2346 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q13085-1 |
| (referenceSequence) | [ModifiedResidue:539121] N6-biotinyl-L-lysine at 786 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13085-1 ACACA (52492)
