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Details on Person UniProt:P18545 PDE6G
| Class:Id | ReferenceGeneProduct:52450 |
|---|---|
| _chainChangeLog | chain:1-87 added on Sat February 7 2015 |
| _displayName | UniProt:P18545 PDE6G |
| _timestamp | 2026-02-20 21:28:34 |
| chain | chain:1-87 |
| checksum | 5D7DEE59D7DDB9E0 |
| comment | FUNCTION Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.CATALYTIC ACTIVITY 3',5'-cyclic GMP + H2O = GMP + H(+)SUBUNIT Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the rod/cone cGMP-PDE gamma subunit family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma shortName: GMP-PDE gamma ecNumber: 3.1.4.35 |
| geneName | PDE6G PDEG |
| identifier | P18545 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation cGMP Hydrolase Proteomics identification Reference proteome Retinitis pigmentosa Sensory transduction Vision |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | PDE6G |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988888] ENSEMBL:ENSG00000185527 PDE6G [Homo sapiens] |
| secondaryIdentifier | CNRG_HUMAN Q3KP63 Q7Z3U8 |
| sequenceLength | 87 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:52449] PDE6G [photoreceptor disc membrane] [Homo sapiens] [EntityWithAccessionedSequence:74052] PDE6G [Homo sapiens] [EntityWithAccessionedSequence:4085973] PDE6G [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P18545 PDE6G (52450)
