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Details on Person UniProt:O43924 PDE6D
| Class:Id | ReferenceGeneProduct:52448 |
|---|---|
| _chainChangeLog | chain:1-150 added on Sat February 7 2015 |
| _displayName | UniProt:O43924 PDE6D |
| _timestamp | 2025-08-15 21:47:38 |
| chain | chain:1-150 |
| checksum | AB8D9309C33B4411 |
| comment | FUNCTION Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Required for RAB28 localization to the cone cell outer segments in the retina (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).SUBUNIT Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains (PDE6A and PDE6B) and two inhibitory chains (gamma); has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane (By similarity). Interacts with prenylated GRK1 and GRK7 (By similarity). Interacts with prenylated Ras family members, including RAP2A and RAP2C (By similarity). Interacts with prenylated RHEB and NRAS (PubMed:22002721). Interacts with prenylated HRAS and KRAS. Interacts with RAB13 (prenylated form); dissociates RAB13 from membranes (PubMed:9712853). Interacts with prenylated INPP5E (PubMed:24166846). Interacts with RAB28 (prenylated form); the interaction promotes RAB28 delivery to the photoreceptor outer segments (By similarity). Interacts with RPGR (PubMed:23559067, PubMed:24166846, PubMed:9990021). Interacts with ARL2 (PubMed:22002721, PubMed:24166846). Interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3 (PubMed:24166846). Interaction with ARL2 and ARL3 promotes release of farnesylated cargo proteins (PubMed:22002721).INTERACTION Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the PDE6D/unc-119 family. |
| description | recommendedName: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta shortName: GMP-PDE delta alternativeName: Protein p17 |
| geneName | PDE6D PDED |
| identifier | O43924 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell projection cGMP Ciliopathy Cytoplasm Cytoplasmic vesicle Cytoskeleton Joubert syndrome Membrane Proteomics identification Reference proteome Sensory transduction Vision |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PDE6D |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997351] ENSEMBL:ENSG00000156973 PDE6D [Homo sapiens] |
| secondaryIdentifier | PDE6D_HUMAN O43250 |
| sequenceLength | 150 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2565921] PDE6D [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5624884] PDE6D [cilium] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43924 PDE6D (52448)
