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Details on Person Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)

Class:Id	Reaction:5244692
_displayName	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)
_doRelease	TRUE
_timestamp	2022-12-19 15:22:00
authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:5244706] histone H3 methyltransferase activity of Core MLL complex, SMYD3, PRDM9 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5244704] Jupe, S, 2014-01-20
edited	[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
input	[CandidateSet:5244740] Me2K5-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5244752] MLL associates specifically with a subset of transcriptionally active target genes [LiteratureReference:5244699] Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus [LiteratureReference:5244751] Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus [LiteratureReference:5244753] Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases [LiteratureReference:4687068] PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex [LiteratureReference:5244703] Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 [LiteratureReference:5637680] SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells [LiteratureReference:1181362] A histone H3 methyltransferase controls epigenetic events required for meiotic prophase
modified	[InstanceEdit:5244781] Jupe, S, 2014-01-21 [InstanceEdit:5627270] Jupe, Steve, 2014-10-17 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5633086] Jassal, Bijay, 2014-10-30 [InstanceEdit:5634799] Jupe, Steve, 2014-11-06 [InstanceEdit:5637656] Jupe, Steve, 2014-11-12 [InstanceEdit:5637682] Jupe, Steve, 2014-11-12 [InstanceEdit:5638142] Jupe, Steve, 2014-11-13 [InstanceEdit:5638320] Jupe, Steve, 2014-11-13 [InstanceEdit:5643672] Jupe, Steve, 2014-11-17 [InstanceEdit:5643684] Jupe, Steve, 2014-11-17 [InstanceEdit:5651814] Jupe, Steve, 2014-11-25 [InstanceEdit:5674563] Jupe, Steve, 2015-02-13 [InstanceEdit:5676065] Jupe, Steve, 2015-02-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9822169] Orlic-Milacic, Marija, 2022-12-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) Core MLL complex, SMYD3, PRDM9 methylate Me2K5-histone H3
output	[CandidateSet:5244761] Me3K5-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9675026] Formation of the MLL1 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [BlackBoxEvent:9818576] Cleaved KMT2A dimers translocate to the nucleus [Homo sapiens] [Reaction:9676255] Formation of the MLL2 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [BlackBoxEvent:9818578] Cleaved KMT2B dimers translocate to the nucleus [Homo sapiens] [Reaction:9676254] Formation of the MLL3 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [Reaction:9676268] Formation of the MLL4 complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [Reaction:9676257] Formation of the SET1A complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [Reaction:9676264] Formation of the SET1B complex [Homo sapiens] [Reaction:9675214] Formation of the WRAD complex [Homo sapiens] [Reaction:5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) [Homo sapiens] [Reaction:9675026] Formation of the MLL1 complex [Homo sapiens] [Reaction:9676255] Formation of the MLL2 complex [Homo sapiens] [Reaction:9676254] Formation of the MLL3 complex [Homo sapiens] [Reaction:9676268] Formation of the MLL4 complex [Homo sapiens] [Reaction:9676257] Formation of the SET1A complex [Homo sapiens] [Reaction:9676264] Formation of the SET1B complex [Homo sapiens] [Reaction:5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) [Homo sapiens]
regulatedBy	[NegativeRegulation:5244782] Negative regulation by 'Me2aR3-histone H3, MeR3-histone H3 [nucleoplasm]'
regulationReference	[RegulationReference:9642694] Negative regulation by 'Me2aR3-histone H3, MeR3-histone H3 [nucleoplasm]' PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation
releaseDate	2015-03-15
reviewed	[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644418] R-HSA-5244692.5
summation	[Summation:5637677] Trimethylation of lysine-5 of histone H3 (H3K4) has been lin...
systematicName	Core MLL complex, SMYD3, PRDM9 transfer CH3 from AdoMet to Me2K5-replicative histone H3
(hasEvent)	[Pathway:3214841] PKMTs methylate histone lysines [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785081] Update Tracker - [Reaction:5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) - v52:[modifyText]
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