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Details on Person botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane]

Class:Id	Complex:5244507
_displayName	botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane]
_timestamp	2020-10-08 22:00:21
compartment	[Compartment:201753] synaptic vesicle membrane
created	[InstanceEdit:5244505] D'Eustachio, Peter, 2014-01-18
disease	[Disease:3632909] botulism
goCellularComponent	[Compartment:5251407] host cell synaptic vesicle membrane
hasComponent	[SimpleEntity:5244439] GT1b [synaptic vesicle membrane] [Complex:5228950] botA HC:LC dimer [synaptic vesicle membrane] [Clostridium botulinum] [Complex:190036] botA LC:Zn2+ [synaptic vesicle membrane] [Clostridium botulinum] [SimpleEntity:5228942] Zn2+ [synaptic vesicle membrane] [EntityWithAccessionedSequence:9616804] botA LC disulfide bonded [synaptic vesicle membrane] [Clostridium botulinum] [EntityWithAccessionedSequence:9616795] botA HC disulfide bonded [synaptic vesicle membrane] [Clostridium botulinum] [DefinedSet:5324682] SV2A,B,C [synaptic vesicle membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5228575] Crystal structure of botulinum neurotoxin type A and implications for toxicity
modified	[InstanceEdit:5244517] D'Eustachio, Peter, 2014-01-18 [InstanceEdit:5250610] D'Eustachio, Peter, 2014-01-28 [InstanceEdit:5251408] D'Eustachio, Peter, 2014-02-04 [InstanceEdit:5324685] D'Eustachio, Peter, 2014-02-17 [InstanceEdit:8959586] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
name	botA HC:LC dimer:SV2:GT1b BoNT/A:SV2:GT1b
relatedSpecies	[Species:168825] Clostridium botulinum
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5647422] R-HSA-5244507.21
(input)	[BlackBoxEvent:5244428] botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol [Homo sapiens]
(output)	[BlackBoxEvent:5244424] botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane [Homo sapiens]
(physicalEntity)	[CatalystActivity:5244412] transmembrane protein transporter activity of botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane]
(replacementInstances)	[_Deleted:5250997] Deletion of instance: 181477 [_Deleted:5251000] Deletion of instance: 194804
(updatedInstance)	[_UpdateTracker:9896606] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v60:[removeSpecies] [_UpdateTracker:9899515] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v66:[updateContainedComponent] [_UpdateTracker:9901803] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v75:[addName, updateContainedComponent]
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No pathways have been reviewed or authored by botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] (5244507)