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Details on Person botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane

Class:Id	BlackBoxEvent:5244424
_displayName	botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane
_doRelease	TRUE
_timestamp	2020-10-08 22:00:26
authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
compartment	[Compartment:876] plasma membrane [Compartment:201753] synaptic vesicle membrane
created	[InstanceEdit:5244399] D'Eustachio, Peter, 2014-01-17
disease	[Disease:3632909] botulism
input	[Complex:5244411] botA HC:LC dimer:SV2:GT1b [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:379281] The synaptic vesicle cycle
modified	[InstanceEdit:5244449] D'Eustachio, Peter, 2014-01-17 [InstanceEdit:5244505] D'Eustachio, Peter, 2014-01-18 [InstanceEdit:5246515] D'Eustachio, Peter, 2014-01-21 [InstanceEdit:5250610] D'Eustachio, Peter, 2014-01-28 [InstanceEdit:5262831] D'Eustachio, Peter, 2014-02-07 [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5324685] D'Eustachio, Peter, 2014-02-17 [InstanceEdit:5333086] D'Eustachio, Peter, 2014-02-18 [InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane
output	[Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] [Homo sapiens]
precedingEvent	[Reaction:5244415] botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface [Homo sapiens] [BlackBoxEvent:5228943] Transcytosis and dissociation of botA:NTNHA:HA [Homo sapiens]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2013-12-04
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644528] R-HSA-5244424.4
summation	[Summation:5262814] Synaptic vesicles re-form rapidly after exocytosis, carrying...
(hasEvent)	[Pathway:5250968] Toxicity of botulinum toxin type A (botA) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5244428] botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol [Homo sapiens]
(replacementInstances)	[_Deleted:5251008] Deletion of instance: 181536
(updatedInstance)	[_UpdateTracker:9776604] Update Tracker - [BlackBoxEvent:5244424] botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane - v75:[modifyText] [_UpdateTracker:9786154] Update Tracker - [BlackBoxEvent:5244424] botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane - v50:[modifyText]
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No pathways have been reviewed or authored by botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (5244424)