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Details on Person UniProt:P35913 PDE6B

Class:Id	ReferenceGeneProduct:52444
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-851 added on Fri February 6 2015;propeptide:852-854 added on Fri February 6 2015;initiator methionine:1 for 52444 removed on Fri Nov 03 2023;initiator methionine: for 52444 added on Fri Nov 03 2023;initiator methionine: for 52444 removed on Fri Aug 15 2025;initiator methionine:1 for 52444 added on Fri Aug 15 2025
_displayName	UniProt:P35913 PDE6B
_timestamp	2025-08-15 22:03:04
chain	initiator methionine:1 chain:2-851 propeptide:852-854
checksum	BB11A519BE88C9DF
comment	FUNCTION Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:20940301). Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (PubMed:8394174).CATALYTIC ACTIVITY 3',5'-cyclic GMP + H2O = GMP + H(+)COFACTOR Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.BIOPHYSICOCHEMICAL PROPERTIES Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cyclic nucleotide phosphodiesterase family.
description	recommendedName: fullName evidence="25"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta shortName: GMP-PDE beta ecNumber evidence="10"3.1.4.35
geneName	PDE6B PDEB
identifier	P35913
isSequenceChanged	FALSE
keyword	Acetylation Alternative splicing Cell projection cGMP Congenital stationary night blindness Disease variant Hydrolase Lipoprotein Magnesium Manganese Membrane Metal-binding Prenylation Proteomics identification Reference proteome Repeat Retinitis pigmentosa Sensory transduction Vision Zinc
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	PDE6B
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8988571] ENSEMBL:ENSG00000133256 PDE6B [Homo sapiens]
secondaryIdentifier	PDE6B_HUMAN B7Z9T9 E7ETT3 Q53XN5 Q9BWH5 Q9UD49
sequenceLength	854
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:424651] UniProt:P35913-1 PDE6B [Homo sapiens] [ReferenceIsoform:424652] UniProt:P35913-2 PDE6B [Homo sapiens] [ReferenceIsoform:8971604] UniProt:P35913-3 PDE6B [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:74446] PDE6B(1-851) [photoreceptor disc membrane] [Homo sapiens] [EntityWithAccessionedSequence:4085974] PDE6B [plasma membrane] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:74445] S-geranylgeranyl-L-cysteine at 851
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No pathways have been reviewed or authored by UniProt:P35913 PDE6B (52444)