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Details on Person botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface

Class:Id	Reaction:5244397
_displayName	botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface
_doRelease	TRUE
_timestamp	2020-10-08 22:00:29
authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5244399] D'Eustachio, Peter, 2014-01-17
disease	[Disease:3632909] botulism
input	[Complex:5228599] botB HC:LC dimer [extracellular region] [Clostridium botulinum] [SimpleEntity:5244403] GT1b [plasma membrane] [DefinedSet:5324686] SYT1,2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:194828] Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells [LiteratureReference:5244426] Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins [LiteratureReference:181709] Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B
modified	[InstanceEdit:5244449] D'Eustachio, Peter, 2014-01-17 [InstanceEdit:5262582] D'Eustachio, Peter, 2014-02-07 [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5324685] D'Eustachio, Peter, 2014-02-17 [InstanceEdit:5333086] D'Eustachio, Peter, 2014-02-18 [InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface
output	[Complex:5244408] botB HC:LC dimer:SYT:GT1b [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5228940] Transcytosis and dissociation of botB:NTNHA:HA [Homo sapiens]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644410] R-HSA-5244397.4
summation	[Summation:5262578] The Botulinum toxin type B disulfide-bonded heavy chain - li...
(hasEvent)	[Pathway:5250958] Toxicity of botulinum toxin type B (botB) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5244402] botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane [Homo sapiens]
(replacementInstances)	[_Deleted:5251022] Deletion of instance: 181359
(updatedInstance)	[_UpdateTracker:9776480] Update Tracker - [Reaction:5244397] botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface - v75:[modifyText]
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No pathways have been reviewed or authored by botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface (5244397)