Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q07343 PDE4B
| Class:Id | ReferenceGeneProduct:52386 |
|---|---|
| _chainChangeLog | chain:1-736 added on Fri February 6 2015 |
| _displayName | UniProt:Q07343 PDE4B |
| _timestamp | 2024-11-03 20:06:53 |
| chain | chain:1-736 |
| checksum | 208FCE9CD40EF5EB |
| comment | FUNCTION Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.CATALYTIC ACTIVITY 3',5'-cyclic AMP + H2O = AMP + H(+)COFACTOR Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions.COFACTOR Binds 2 divalent metal cations per subunit. Site 2 has a preference for magnesium and/or manganese ions.ACTIVITY REGULATION Inhibited by rolipram.BIOPHYSICOCHEMICAL PROPERTIES Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.SUBUNIT Interacts with DISC1.INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015).TISSUE SPECIFICITY Brain-specific isoform.SIMILARITY Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="21"3',5'-cyclic-AMP phosphodiesterase 4B ecNumber evidence="7 10 13 14"3.1.4.53 alternativeName: DPDE4 alternativeName: PDE32 alternativeName: fullName evidence="21"cAMP-specific phosphodiesterase 4B |
| geneName | PDE4B DPDE4 |
| identifier | Q07343 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing cAMP Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Phosphoprotein Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PDE4B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992037] ENSEMBL:ENSG00000184588 PDE4B [Homo sapiens] |
| secondaryIdentifier | PDE4B_HUMAN A5YW33 O15443 Q13945 Q5TEK4 Q5TEK5 Q5TEK6 |
| sequenceLength | 736 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145675] UniProt:Q07343-2 PDE4B [Homo sapiens] [ReferenceIsoform:145676] UniProt:Q07343-3 PDE4B [Homo sapiens] [ReferenceIsoform:405244] UniProt:Q07343-1 PDE4B [Homo sapiens] [ReferenceIsoform:8975255] UniProt:Q07343-4 PDE4B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:52385] PDE4B [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:177291] O-phospho-L-serine at 54 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q07343 PDE4B (52386)
