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Details on Person UniProt:Q01064 PDE1B
| Class:Id | ReferenceGeneProduct:52372 |
|---|---|
| _chainChangeLog | chain:1-536 added on Sat February 7 2015 |
| _displayName | UniProt:Q01064 PDE1B |
| _timestamp | 2025-08-15 21:55:23 |
| chain | chain:1-536 |
| checksum | D15211AC32C756A4 |
| comment | FUNCTION Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). Has a preference for cGMP as a substrate (PubMed:9419816).CATALYTIC ACTIVITY a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)CATALYTIC ACTIVITY 3',5'-cyclic GMP + H2O = GMP + H(+)CATALYTIC ACTIVITY 3',5'-cyclic AMP + H2O = AMP + H(+)COFACTOR Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions.COFACTOR Binds 2 divalent metal cations per subunit. Site 2 has a preference for magnesium ions.ACTIVITY REGULATION Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).SUBUNIT Homodimer.INTERACTION Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. |
| description | recommendedName: fullName evidence="15"Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B shortName: Cam-PDE 1B ecNumber evidence="6 7 8"3.1.4.17 alternativeName: fullName evidence="10"63 kDa Cam-PDE |
| geneName | PDE1B PDES1B |
| identifier | Q01064 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calmodulin-binding cAMP cGMP Cytoplasm Hydrolase Metal-binding Phosphoprotein Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PDE1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988570] ENSEMBL:ENSG00000123360 PDE1B [Homo sapiens] |
| secondaryIdentifier | PDE1B_HUMAN Q92825 Q96KP3 |
| sequenceLength | 536 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971602] UniProt:Q01064-1 PDE1B [Homo sapiens] [ReferenceIsoform:8971603] UniProt:Q01064-2 PDE1B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:52371] PDE1B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9014908] activated PDE1B [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q01064 PDE1B (52372)
