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Details on Person UniProt:P78382 SLC35A1
| Class:Id | ReferenceGeneProduct:52362 |
|---|---|
| _chainChangeLog | chain:1-337 added on Sat February 7 2015 |
| _displayName | UniProt:P78382 SLC35A1 |
| _timestamp | 2025-02-21 19:12:12 |
| chain | chain:1-337 |
| checksum | 508DD77F5EEBB5A7 |
| comment | FUNCTION Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP (PubMed:12682060, PubMed:15576474, PubMed:23873973). Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity). Also able to exchange CMP-sialic acid for AMP and UMP (PubMed:12682060). Also mediates the transport of CDP-ribitol (By similarity).CATALYTIC ACTIVITY CMP-N-acetyl-beta-neuraminate(in) + CMP(out) = CMP-N-acetyl-beta-neuraminate(out) + CMP(in)CATALYTIC ACTIVITY CMP-N-acetyl-beta-neuraminate(in) + AMP(out) = CMP-N-acetyl-beta-neuraminate(out) + AMP(in)CATALYTIC ACTIVITY CDP-L-ribitol(in) + CDP(out) = CDP-L-ribitol(out) + CDP(in)CATALYTIC ACTIVITY UMP(out) + CMP-N-acetyl-beta-neuraminate(in) = UMP(in) + CMP-N-acetyl-beta-neuraminate(out)BIOPHYSICOCHEMICAL PROPERTIES Monomer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the nucleotide-sugar transporter family. SLC35A subfamily. |
| description | recommendedName: fullName evidence="9"CMP-sialic acid transporter shortName: CMP-SA-Tr shortName: CMP-Sia-Tr shortName evidence="9"CST alternativeName: Solute carrier family 35 member A1 |
| geneName | SLC35A1 |
| identifier | P78382 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Antiport Congenital disorder of glycosylation Disease variant Golgi apparatus Membrane Proteomics identification Reference proteome Sugar transport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC35A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000829] ENSEMBL:ENSG00000164414 SLC35A1 [Homo sapiens] |
| secondaryIdentifier | S35A1_HUMAN Q5W1L8 |
| sequenceLength | 337 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976213] UniProt:P78382-1 SLC35A1 [Homo sapiens] [ReferenceIsoform:8976214] UniProt:P78382-2 SLC35A1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:727812] SLC35A1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:5651957] SLC35A1 V93Cfs*17 [Golgi membrane] [Homo sapiens] |
| (referenceSequence) | [FragmentReplacedModification:5651983] Replacement of residues 93 to 108 by CIVSVCCSEQHGFPSS |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P78382 SLC35A1 (52362)
