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Details on Person UniProt:P84088 CPLX2
| Class:Id | ReferenceGeneProduct:52344 |
|---|---|
| _chainChangeLog | chain:1-134 added on Fri February 6 2015 |
| _displayName | UniProt:P84088 CPLX2 |
| _timestamp | 2023-11-03 17:22:31 |
| chain | chain:1-134 |
| checksum | 7791812FD4194AC5 |
| comment | FUNCTION Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis.SUBUNIT Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.SUBCELLULAR LOCATION Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.TISSUE SPECIFICITY Nervous system. Also present in adrenal chromaffin cells (at protein level).SIMILARITY Belongs to the complexin/synaphin family. |
| description | recommendedName: Complexin-2 alternativeName: Complexin II shortName: CPX II alternativeName: fullName evidence="7"Synaphin-1 |
| geneName | CPLX2 |
| identifier | P84088 |
| isSequenceChanged | FALSE |
| keyword | Cell projection Coiled coil Cytoplasm Direct protein sequencing Exocytosis Mast cell degranulation Neurotransmitter transport Nucleus Phosphoprotein Reference proteome Synapse Transport |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | CPLX2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CPLX2_BOVIN O09056 Q13329 Q28184 Q64386 |
| sequenceLength | 134 |
| species | [Species:48898] Bos taurus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P84088 CPLX2 (52344)
