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Details on Person UniProt:Q9Y271 CYSLTR1
| Class:Id | ReferenceGeneProduct:52330 |
|---|---|
| _chainChangeLog | chain:1-337 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y271 CYSLTR1 |
| _timestamp | 2024-11-03 19:45:08 |
| chain | chain:1-337 |
| checksum | B9B53940F895F245 |
| comment | FUNCTION Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.SUBCELLULAR LOCATION Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.MISCELLANEOUS Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: Cysteinyl leukotriene receptor 1 shortName: CysLTR1 alternativeName: Cysteinyl leukotriene D4 receptor shortName: LTD4 receptor alternativeName: G-protein coupled receptor HG55 alternativeName: HMTMF81 |
| geneName | CYSLTR1 CYSLT1 |
| identifier | Q9Y271 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CYSLTR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990608] ENSEMBL:ENSG00000173198 CYSLTR1 [Homo sapiens] |
| secondaryIdentifier | CLTR1_HUMAN B2R954 D3DTE4 Q5JS94 Q8IV19 |
| sequenceLength | 337 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:416418] CYSLTR1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y271 CYSLTR1 (52330)
