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Details on Person Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes

Class:Id	BlackBoxEvent:5229348
_displayName	Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
_doRelease	TRUE
_timestamp	2016-11-03 14:09:41
authored	[InstanceEdit:5228768] Rothfels, K, 2014-01-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5229349] Rothfels, K, 2014-01-17
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
input	[CandidateSet:4411390] 'canonical' WNT target genes [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3238089] The way Wnt works: Components and mechanism [LiteratureReference:5229346] Context-dependent regulation of Groucho/TLE-mediated repression [LiteratureReference:5334041] The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines [LiteratureReference:5334038] TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription [LiteratureReference:5334036] A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
modified	[InstanceEdit:5251694] Rothfels, K, 2014-02-04 [InstanceEdit:5323655] Rothfels, K, 2014-02-15 [InstanceEdit:5339740] Rothfels, K, 2014-03-07 [InstanceEdit:5358703] Rothfels, Karen, 2014-03-31 [InstanceEdit:5358811] Rothfels, Karen, 2014-04-03 [InstanceEdit:5422959] Rothfels, Karen, 2014-05-07 [InstanceEdit:6782938] Rothfels, Karen, 2015-06-09 [InstanceEdit:8944135] Rothfels, Karen, 2016-11-03 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
output	[CandidateSet:4411358] 'canonical' WNT target gene transcripts [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:4641231] TLE recruits HDAC1 to WNT promoters [Homo sapiens] [Reaction:8944349] TLE tetramers bind TCF/LEF at WNT promoters [Homo sapiens] [Reaction:5334050] TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:5229351] Negative gene expression regulation by ''canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm]' [NegativeGeneExpressionRegulation:5339676] Negative gene expression regulation by 'TCF7L2/TCF7L1:CTBPs [nucleoplasm]'
releaseDate	2014-06-10
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644827] R-HSA-5229348.5
summation	[Summation:5229347] Transcription of WNT genes is repressed in the absence of WN...
(hasEvent)	[Pathway:4641265] Repression of WNT target genes [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782247] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v59:[add_removeRegulator] [_UpdateTracker:9786170] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v50:[add_removeRegulator]
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