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Details on Person AXIN is phosphorylated in the destruction complex

Class:Id	Reaction:5229343
_displayName	AXIN is phosphorylated in the destruction complex
_doRelease	TRUE
_timestamp	2016-10-05 19:05:24
authored	[InstanceEdit:5229354] Rothfels, K, 2014-01-17
catalystActivity	[CatalystActivity:5229341] protein serine/threonine kinase activity of AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5229345] Rothfels, K, 2014-01-17
edited	[InstanceEdit:5323556] Rothfels, K, 2014-02-15
input	[Complex:195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5229342] Wnt stabilization of ?-catenin reveals principles for morphogen receptor-scaffold assemblies [LiteratureReference:3640789] Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin [LiteratureReference:208113] Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex [LiteratureReference:208242] A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression [LiteratureReference:5140717] An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis [LiteratureReference:208273] Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability [LiteratureReference:4641111] Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex [LiteratureReference:3238089] The way Wnt works: Components and mechanism
modified	[InstanceEdit:5251574] Rothfels, K, 2014-02-04 [InstanceEdit:5323556] Rothfels, K, 2014-02-15 [InstanceEdit:5334723] Matthews, Lisa, 2014-02-25 [InstanceEdit:5433080] Rothfels, Karen, 2014-05-12 [InstanceEdit:8941690] Rothfels, Karen, 2016-10-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AXIN is phosphorylated in the destruction complex
output	[Complex:3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:195251] Assembly of the destruction complex [Homo sapiens] [Reaction:5246693] APC is K63-polyubiquitinated [Homo sapiens] [BlackBoxEvent:5251557] Expression of AMER1 gene [Homo sapiens] [BlackBoxEvent:5251555] Expression of AXIN1 gene [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5433076] Salahshor, S, 2014-05-12
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644833] R-HSA-5229343.3
summation	[Summation:5229344] In the absence of WNT signal, AXIN is a phosphoprotein; cand...
(hasEvent)	[Pathway:195253] Degradation of beta-catenin by the destruction complex [Homo sapiens]
(precedingEvent)	[Reaction:195304] Association of beta-catenin with the destruction complex [Homo sapiens]
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