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Details on Person Transcytosis and dissociation of botA:NTNHA:HA

Class:Id	BlackBoxEvent:5228943
_displayName	Transcytosis and dissociation of botA:NTNHA:HA
_doRelease	TRUE
_timestamp	2020-10-08 22:00:14
authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:5228945] D'Eustachio, Peter, 2014-01-14
disease	[Disease:3632909] botulism
input	[Complex:5228604] botA HC:LC dimer:NTNHA:HA [extracellular region] [Clostridium botulinum]
isChimeric	FALSE
literatureReference	[LiteratureReference:5228944] Uptake of botulinum neurotoxin in the intestine [LiteratureReference:5228606] Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity [LiteratureReference:5251392] Identification of the major steps in botulinum toxin action
modified	[InstanceEdit:5228949] D'Eustachio, Peter, 2014-01-14 [InstanceEdit:5244399] D'Eustachio, Peter, 2014-01-17 [InstanceEdit:5250610] D'Eustachio, Peter, 2014-01-28 [InstanceEdit:5251709] D'Eustachio, Peter, 2014-02-04 [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5324685] D'Eustachio, Peter, 2014-02-17 [InstanceEdit:5333086] D'Eustachio, Peter, 2014-02-18 [InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transcytosis and dissociation of botA:NTNHA:HA
output	[Complex:5228590] botA HC:LC dimer [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228601] NTNHA [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228602] ha17 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228602] ha17 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228602] ha17 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228607] ha33 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228607] ha33 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228607] ha33 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228607] ha33 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228607] ha33 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228607] ha33 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228591] ha70 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228591] ha70 [extracellular region] [Clostridium botulinum] [EntityWithAccessionedSequence:5228591] ha70 [extracellular region] [Clostridium botulinum]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644269] R-HSA-5228943.4
summation	[Summation:5251718] The bacterial botA:NTNHA:HA (BoNT/A:NTNHA:HA) complex, consi...
(hasEvent)	[Pathway:5250968] Toxicity of botulinum toxin type A (botA) [Homo sapiens]
(precedingEvent)	[Reaction:5244415] botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776511] Update Tracker - [BlackBoxEvent:5228943] Transcytosis and dissociation of botA:NTNHA:HA - v75:[modifyText] [_UpdateTracker:9786111] Update Tracker - [BlackBoxEvent:5228943] Transcytosis and dissociation of botA:NTNHA:HA - v50:[modifyText]
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