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Details on Person Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG

Class:Id	FailedReaction:5228840
_displayName	Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG
_doRelease	TRUE
_timestamp	2019-02-21 02:12:58
authored	[InstanceEdit:5545427] Shamovsky, V, 2014-05-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5228861] Shamovsky, V, 2014-01-14
disease	[Disease:5433062] severe combined immunodeficiency
edited	[InstanceEdit:5673719] Shamovsky, Veronica, 2015-02-09
entityFunctionalStatus	[EntityFunctionalStatus:9637848] loss_of_function of IKBKB Q432Pfs*62 [cytosol]
input	[EntityWithAccessionedSequence:168108] IKBKG [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168104] CHUK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9628518] IKBKB Q432Pfs*62 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5228878] Deficiency of innate and acquired immunity caused by an IKBKB mutation
modified	[InstanceEdit:5263018] Shamovsky, V, 2014-02-09 [InstanceEdit:5602299] Shamovsky, Veronica, 2014-06-23 [InstanceEdit:5602777] Shamovsky, Veronica, 2014-06-24 [InstanceEdit:5609678] Shamovsky, Veronica, 2014-07-16 [InstanceEdit:5609679] Shamovsky, Veronica, 2014-07-16 [InstanceEdit:5609680] Shamovsky, Veronica, 2014-07-16 [InstanceEdit:5609681] Shamovsky, Veronica, 2014-07-16 [InstanceEdit:5625553] Shamovsky, Veronica, 2014-10-06 [InstanceEdit:5627001] Shamovsky, Veronica, 2014-10-14 [InstanceEdit:5627581] Shamovsky, Veronica, 2014-10-20 [InstanceEdit:5633253] Matthews, Lisa, 2014-10-31 [InstanceEdit:5635723] Shamovsky, Veronica, 2014-11-07 [InstanceEdit:5643753] Shamovsky, Veronica, 2014-11-17 [InstanceEdit:5675061] Shamovsky, Veronica, 2015-02-15 [InstanceEdit:5675794] Shamovsky, Veronica, 2015-02-16 [InstanceEdit:9628516] Shamovsky, Veronica, 2018-11-09 [InstanceEdit:9637849] Shamovsky, Veronica, 2019-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG
normalReaction	[Reaction:5609665] CHUK, IKBKB and IKBKG form IKK complex [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5621924] D'Eustachio, Peter, 2014-09-06 [InstanceEdit:5675062] McDonald, Douglas R, 2015-02-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680028] R-HSA-5228840.4
summation	[Summation:5228867] I kappa B kinase B (IKBKB or IKK beta) is the catalytic subu...
systematicName	Defective IKBKB does not bind IKKA, IKBKG
(hasEvent)	[Pathway:5602636] IKBKB deficiency causes SCID [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778920] Update Tracker - [FailedReaction:5228840] Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG - v67:[addInput]
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