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Details on Person RANBP2 SUMOylates MDM2 with SUMO1

Class:Id	Reaction:5228523
_displayName	RANBP2 SUMOylates MDM2 with SUMO1
_doRelease	TRUE
_timestamp	2022-01-19 16:44:42
authored	[InstanceEdit:2997736] May, B, 2013-01-23
catalystActivity	[CatalystActivity:3000418] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
catalystActivityReference	[CatalystActivityReference:9644133] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:5228504] May, B, 2014-01-13
edited	[InstanceEdit:2997736] May, B, 2013-01-23
input	[EntityWithAccessionedSequence:69486] MDM2 [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3000412] Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes
modified	[InstanceEdit:3065680] May, B, 2013-02-06 [InstanceEdit:3730900] May, B, 2013-06-16 [InstanceEdit:4663810] May, B, 2013-10-06 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933464] May, Bruce, 2016-08-04 [InstanceEdit:8934412] May, Bruce, 2016-08-09 [InstanceEdit:9608079] May, Bruce, 2018-05-09 [InstanceEdit:9615866] May, Bruce, 2018-08-08 [InstanceEdit:9644134] May, Bruce, 2019-04-08 [InstanceEdit:9762281] May, Bruce, 2022-01-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RANBP2 SUMOylates MDM2 with SUMO1 Conjugation of SUMO1 to MDM2
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3000408] monoSUMO1-K182-MDM2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
releaseDate	2018-06-12
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8908471] R-HSA-5228523.5
summation	[Summation:4663728] RANBP2 of the nuclear pore complex SUMOylates MDM2 with SUMO...
(hasEvent)	[Pathway:3232142] SUMOylation of ubiquitinylation proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775250] Update Tracker - [Reaction:5228523] RANBP2 SUMOylates MDM2 with SUMO1 - v80:[add_removeOutput]
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No pathways have been reviewed or authored by RANBP2 SUMOylates MDM2 with SUMO1 (5228523)