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Details on Person PIAS1,4 SUMOylate CASP8AP2 with SUMO1

Class:Id	Reaction:5228521
_displayName	PIAS1,4 SUMOylate CASP8AP2 with SUMO1
_doRelease	TRUE
_timestamp	2022-01-19 16:40:36
authored	[InstanceEdit:3903025] May, B, 2013-07-16
catalystActivity	[CatalystActivity:2997675] SUMO transferase activity of PIAS1,4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5228504] May, B, 2014-01-13
edited	[InstanceEdit:3903025] May, B, 2013-07-16
input	[EntityWithAccessionedSequence:3927945] CASP8AP2 [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3927931] SUMO modification regulates the transcriptional activity of FLASH [LiteratureReference:3927949] PIAS1 interacts with FLASH and enhances its co-activation of c-Myb [LiteratureReference:8953827] SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2
modified	[InstanceEdit:5626908] May, Bruce, 2014-10-13 [InstanceEdit:5685857] May, Bruce, 2015-03-30 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8953853] May, Bruce, 2016-12-29 [InstanceEdit:9608079] May, Bruce, 2018-05-09 [InstanceEdit:9615866] May, Bruce, 2018-08-08 [InstanceEdit:9762281] May, Bruce, 2022-01-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 PIAS1,PIAS4 SUMOylate FLASH
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3927850] monoSUMO1-K1813-CASP8AP2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
releaseDate	2018-06-12
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8925805] R-HSA-5228521.4
summation	[Summation:3927831] PIAS1, PIAS4 SUMOylate CASP8AP2 (FLASH) at lysine-1813 with ...
(hasEvent)	[Pathway:3899300] SUMOylation of transcription cofactors [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775051] Update Tracker - [Reaction:5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - v80:[add_removeOutput]
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No pathways have been reviewed or authored by PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (5228521)