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Details on Person As inferred from the mouse homolog, ARNTL is SUMOylated pref...
| Class:Id | Summation:5228471 |
|---|---|
| _displayName | As inferred from the mouse homolog, ARNTL is SUMOylated pref... |
| _timestamp | 2015-03-08 13:32:37 |
| created | [InstanceEdit:5228478] May, B, 2014-01-12 |
| modified | [InstanceEdit:5627417] May, Bruce, 2014-10-18 [InstanceEdit:5682545] May, Bruce, 2015-03-08 |
| text | As inferred from the mouse homolog, ARNTL is SUMOylated preferentially with SUMO2,3 at lysine-252 and lysine-259. SUMOylation is also observed in proteomic analysis of human cells (Hendriks et al. 2014). SUMOylation at lysine-259 requires CLOCK protein and is maximal at ZT9 in the circadian rhythm when ARNTL is phosphorylated and dimerized with CLOCK. SUMOylation causes localization of ARNTL to PML bodies. SUMOylated ARNTL has higher transcriptional activation activity but is destablized by ubiquitinylation and proteasomal degradation. |
| (summation) | [BlackBoxEvent:5228482] SUMOylation of BMAL1 with SUMO2,3 [Homo sapiens] |
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No pathways have been reviewed or authored by As inferred from the mouse homolog, ARNTL is SUMOylated pref... (5228471)
