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Details on Person tetX HC transports tetX LC from target cell endosome membrane into cytosol

Class:IdBlackBoxEvent:5228406
_displayNametetX HC transports tetX LC from target cell endosome membrane into cytosol
_doReleaseTRUE
_timestamp2020-10-08 22:01:41
authored[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
catalystActivity[CatalystActivity:5228410] transmembrane protein transporter activity of tetX:gangliosides [endocytic vesicle membrane]
catalystActivityReference[CatalystActivityReference:9643375] protein transmembrane transporter activity of TeNT:gangliosides [endocytic vesicle membrane] Botulinum neurotoxin: a marvel of protein design
compartment[Compartment:70101] cytosol
[Compartment:24337] endocytic vesicle membrane
created[InstanceEdit:5228409] D'Eustachio, Peter, 2014-01-10
disease[Disease:5228387] tetanus
input[Complex:5228374] tetX:gangliosides [endocytic vesicle membrane] [Clostridium tetani]
isChimericFALSE
literatureReference[LiteratureReference:5228359] Botulinum neurotoxin: a marvel of protein design
modified[InstanceEdit:5228412] D'Eustachio, Peter, 2014-01-10
[InstanceEdit:5228577] D'Eustachio, Peter, 2014-01-14
[InstanceEdit:5244399] D'Eustachio, Peter, 2014-01-17
[InstanceEdit:5250512] D'Eustachio, Peter, 2014-01-25
[InstanceEdit:5250610] D'Eustachio, Peter, 2014-01-28
[InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11
[InstanceEdit:5324688] D'Eustachio, Peter, 2014-02-17
[InstanceEdit:5333086] D'Eustachio, Peter, 2014-02-18
[InstanceEdit:5334717] D'Eustachio, Peter, 2014-02-25
[InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23
[InstanceEdit:5628835] D'Eustachio, Peter, 2014-10-23
[InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nametetX HC transports tetX LC from target cell endosome membrane into cytosol
output[EntityWithAccessionedSequence:5228393] tetX HC [endocytic vesicle membrane] [Clostridium tetani]
[Complex:5228371] tetX LC:Zn2+ [cytosol] [Clostridium tetani]
[SimpleEntity:5228361] GD3 [endocytic vesicle membrane]
[SimpleEntity:5228364] GM1a [endocytic vesicle membrane]
precedingEvent
regulatedBy[PositiveRegulation:5228593] Positive regulation by 'H+ [endocytic vesicle lumen]'
regulationReference[RegulationReference:9642717] Positive regulation by 'H+ [endocytic vesicle lumen]' Botulinum neurotoxin: a marvel of protein design
relatedSpecies[Species:5228399] Clostridium tetani
releaseDate2014-12-11
reviewed[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25
[InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5622263] R-HSA-5228406.6
summation[Summation:5263584] Acidification of the vesicle containing tetanus toxin disulf...
(hasEvent)[Pathway:5250982] Toxicity of tetanus toxin (tetX) [Homo sapiens]
(precedingEvent)[Reaction:5228578] tetX LC cleaves target cell VAMP2 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776497] Update Tracker - [BlackBoxEvent:5228406] tetX HC transports tetX LC from target cell endosome membrane into cytosol - v75:[modifyText]
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