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Details on Person UniProt:P56748 CLDN8
| Class:Id | ReferenceGeneProduct:52246 |
|---|---|
| _chainChangeLog | chain:1-225 added on Fri February 6 2015 |
| _displayName | UniProt:P56748 CLDN8 |
| _timestamp | 2024-11-03 19:50:28 |
| chain | chain:1-225 |
| checksum | F7920E8E71682473 |
| comment | FUNCTION Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). Cannot form tight junction strands on its own (PubMed:36008380).CATALYTIC ACTIVITY chloride(in) = chloride(out)CATALYTIC ACTIVITY bromide(in) = bromide(out)CATALYTIC ACTIVITY iodide(out) = iodide(in)CATALYTIC ACTIVITY fluoride(in) = fluoride(out)SUBUNIT Can form heteropolymeric strands with other claudins (PubMed:36008380). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with CLDN4; forms coassem. Interacts with KLHL3.INTERACTION Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.TISSUE SPECIFICITY Expressed in the epididymis, mainly in the caput segment.PTM Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation.SIMILARITY Belongs to the claudin family. |
| description | recommendedName: Claudin-8 |
| geneName | CLDN8 UNQ779/PRO1573 |
| identifier | P56748 |
| isSequenceChanged | FALSE |
| keyword | Cell junction Cell membrane Membrane Proteomics identification Reference proteome Tight junction Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CLDN8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989448] ENSEMBL:ENSG00000156284 CLDN8 [Homo sapiens] |
| secondaryIdentifier | CLD8_HUMAN D3DSE3 Q53EX7 |
| sequenceLength | 225 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:419968] CLDN8 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:421243] CLDN8 [cell junction] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P56748 CLDN8 (52246)
