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Details on Person UniProt:O95471 CLDN7
Class:Id
ReferenceGeneProduct:52244
_chainChangeLog
chain:1-211 added on Fri February 6 2015
_displayName
UniProt:O95471 CLDN7
_timestamp
2024-11-03 19:50:28
chain
chain:1-211
checksum
7F3CC1B963D9006A
comment
FUNCTION Plays a major role in tight junction-specific obliteration of the intercellular space.SUBUNIT Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM (PubMed:16054130). Does not interact with CD81 (PubMed:20375010).INTERACTION Co-localizes with EPCAM at the basolateral cell membrane and tight junction.ALTERNATIVE PRODUCTS Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.INDUCTION By androgens.PTM Phosphorylated.SIMILARITY Belongs to the claudin family.
