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Details on Person UniProt:P57739 CLDN2
| Class:Id | ReferenceGeneProduct:52234 |
|---|---|
| _chainChangeLog | chain:1-230 added on Fri February 6 2015 |
| _displayName | UniProt:P57739 CLDN2 |
| _timestamp | 2024-11-03 20:13:45 |
| chain | chain:1-230 |
| checksum | 52CA642D4A62B70D |
| comment | FUNCTION Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:20460438, PubMed:36008380). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response (By similarity). In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream (By similarity). In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients (By similarity).CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY Rb(+)(in) = Rb(+)(out)CATALYTIC ACTIVITY Li(+)(in) = Li(+)(out)CATALYTIC ACTIVITY Cs(+)(in) = Cs(+)(out)CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY methylamine(out) = methylamine(in)CATALYTIC ACTIVITY choline(out) = choline(in)CATALYTIC ACTIVITY H2O(in) = H2O(out)SUBUNIT Can form homo- and heteropolymers with other claudins to mediate paracellular barrier and channel functions of tight junctions in response to physiological stimuli. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.INTERACTION The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the claudin family. |
| description | recommendedName: fullName evidence="9"Claudin-2 alternativeName: SP82 |
| geneName | CLDN2 PSEC0059 SP82 UNQ705/PRO1356 |
| identifier | P57739 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell junction Cell membrane Disease variant Disulfide bond Isopeptide bond Membrane Phosphoprotein Proteomics identification Reference proteome Tight junction Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CLDN2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003452] ENSEMBL:ENSG00000165376 CLDN2 [Homo sapiens] |
| secondaryIdentifier | CLD2_HUMAN B2R6B9 |
| sequenceLength | 230 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:419994] CLDN2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:421235] CLDN2 [cell junction] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P57739 CLDN2 (52234)
