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Details on Person ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)

Class:IdReaction:5223313
_displayNameABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)
_doReleaseTRUE
_timestamp2022-02-14 15:46:53
authored[InstanceEdit:5223335] Jassal, Bijay, 2014-01-06
catalystActivity[CatalystActivity:5223338] ABC-type vitamin B12 transporter activity of ABCD4:LMBRD1 [lysosomal membrane]
catalystActivityReference[CatalystActivityReference:9730748] ABC-type vitamin B12 transporter activity of ABCD4:LMBRD1 [lysosomal membrane] The lysosomal protein ABCD4 can transport vitamin B12 across liposomal membranes in vitro
compartment[Compartment:70101] cytosol
[Compartment:161320] lysosomal lumen
[Compartment:17938] lysosomal membrane
created[InstanceEdit:5223335] Jassal, Bijay, 2014-01-06
edited[InstanceEdit:5223335] Jassal, Bijay, 2014-01-06
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:9759390] RCbl [lysosomal lumen]
isChimericFALSE
literatureReference[LiteratureReference:3928676] Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism
[LiteratureReference:9758824] Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1
[LiteratureReference:9730745] The lysosomal protein ABCD4 can transport vitamin B12 across liposomal membranes in vitro
[LiteratureReference:3000283] Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism
[LiteratureReference:9758708] Defect in vitamin B12 release from lysosomes: newly described inborn error of vitamin B12 metabolism
modified[InstanceEdit:5621564] Jassal, Bijay, 2014-09-01
[InstanceEdit:9730743] D'Eustachio, Peter, 2021-05-10
[InstanceEdit:9730763] Jassal, Bijay, 2021-05-11
[InstanceEdit:9730860] D'Eustachio, Peter, 2021-05-11
[InstanceEdit:9749834] Jassal, Bijay, 2021-08-06
[InstanceEdit:9758887] D'Eustachio, Peter, 2021-11-26
[InstanceEdit:9758898] D'Eustachio, Peter, 2021-11-26
[InstanceEdit:9759431] D'Eustachio, Peter, 2021-12-03
[InstanceEdit:9760391] D'Eustachio, Peter, 2021-12-17
[InstanceEdit:9764875] D'Eustachio, Peter, 2022-02-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)
an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate
negativePrecedingEvent[NegativePrecedingEvent:9764883] Different Cell Type: TCN2:RCbl is degraded to release RCbl
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:9759394] RCbl [cytosol]
precedingEvent
releaseDate2014-09-30
reviewed[InstanceEdit:5621563] Rosenblatt, David, 2014-09-01
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9730861] D'Eustachio, Peter, 2021-05-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5622333] R-HSA-5223313.5
summation[Summation:5223327] In the mucosal cells of the distal ileum, ATP binding casset...
(hasEvent)[Pathway:9758881] Uptake of dietary cobalamins into enterocytes [Homo sapiens]
(normalReaction)[FailedReaction:5683325] Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol [Homo sapiens]
(precedingEvent)[Reaction:3095901] ABCC1 transports cytosolic RCbl to extracellular region [Homo sapiens]
[NegativePrecedingEvent:9764873] Different Cell Type: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)
(replacementInstances)[_Deleted:9730755] Deletion of instance: 3000238
(updatedInstance)[_UpdateTracker:9775061] Update Tracker - [Reaction:5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) - v80:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9776137] Update Tracker - [Reaction:5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) - v77:[addLiteratureReference, modifyText]
[_UpdateTracker:9784867] Update Tracker - [Reaction:5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) - v52:[modifyText]
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