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Details on Person UniProt:Q99895 CTRC
| Class:Id | ReferenceGeneProduct:52230 |
|---|---|
| _chainChangeLog | signal peptide:1-16 added on Sat February 7 2015;propeptide:17-29 added on Sat February 7 2015;chain:30-268 added on Sat February 7 2015 |
| _displayName | UniProt:Q99895 CTRC |
| _timestamp | 2024-11-03 19:50:38 |
| chain | signal peptide:1-16 propeptide:17-29 chain:30-268 |
| checksum | 460BF33B4A96516F |
| comment | FUNCTION Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.CATALYTIC ACTIVITY Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.INTERACTION Pancreas.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235).SIMILARITY Belongs to the peptidase S1 family. Elastase subfamily. |
| description | recommendedName: Chymotrypsin-C ecNumber: 3.4.21.2 alternativeName: Caldecrin |
| geneName | CTRC CLCR |
| identifier | Q99895 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant Disulfide bond Glycoprotein Hydrolase Protease Proteomics identification Reference proteome Serine protease Signal Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CTRC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988903] ENSEMBL:ENSG00000162438 CTRC [Homo sapiens] |
| secondaryIdentifier | CTRC_HUMAN A8K082 O00765 Q9NUH5 |
| sequenceLength | 268 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5693362] CTRC [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9922787] pro-CTRC [zymogen granule] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q99895 CTRC (52230)
