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Details on Person TDG excises 5-carboxylcytosine

Class:Id	Reaction:5221061
_displayName	TDG excises 5-carboxylcytosine
_doRelease	TRUE
_timestamp	2024-04-12 14:18:06
authored	[InstanceEdit:5220992] May, B, 2013-12-28
catalystActivity	[CatalystActivity:110209] DNA N-glycosylase activity of TDG [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5221003] May, B, 2013-12-30
edited	[InstanceEdit:5220992] May, B, 2013-12-28
goBiologicalProcess	[GO_BiologicalProcess:9907540] chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
input	[EntityWithAccessionedSequence:65812] TDG [nucleoplasm] [Homo sapiens] [OtherEntity:5220996] DNA containing 5-caC [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5220924] Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites [LiteratureReference:5221043] Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA [LiteratureReference:5221038] Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation [LiteratureReference:5221024] Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA [LiteratureReference:5222403] Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition
modified	[InstanceEdit:5221120] May, B, 2014-01-01 [InstanceEdit:5222407] May, B, 2014-01-03 [InstanceEdit:5250677] May, B, 2014-01-29 [InstanceEdit:5333792] May, B, 2014-02-21 [InstanceEdit:9821924] D'Eustachio, Peter, 2022-12-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9907541] D'Eustachio, Peter, 2024-04-12
name	TDG excises 5-carboxylcytosine
output	[Complex:110191] TDG:AP-dsDNA [nucleoplasm] [Homo sapiens] [SimpleEntity:5221064] 5-caC [nucleoplasm]
precedingEvent	[Reaction:5220952] TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine [Homo sapiens] [Reaction:5220990] TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5250662] Pfeifer, Gerd P, 2014-01-29 [InstanceEdit:5333791] Mukherji, Mridul, 2014-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644755] R-HSA-5221061.4
summation	[Summation:5222405] Thymine DNA glycosylase (TDG) excises 5-carboxylcytosine (5-...
(hasEvent)	[Pathway:5221030] TET1,2,3 and TDG demethylate DNA [Homo sapiens]
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